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Aclaris Therapeutics (ACRS) investor relations material
Aclaris Therapeutics Jefferies London Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Jefferies London Healthcare Conference 2025 summary17 Nov, 2025
Pipeline overview and strategic focus
Four clinical-stage assets expected by 2026, including both small molecules and biologics.
Lead small molecule (2138) showed positive data in atopic dermatitis; next-gen ITK inhibitor to enter IND in late 2026.
Biologics pipeline centers on TSLP MAB (045) and a bispecific TSLP/IL4R antibody, both targeting atopic dermatitis and respiratory diseases.
Bispecific antibody is progressing through SAD/MAD studies, with data expected in early 2026.
Preclinical asset to advance to IND in 2026, expanding clinical portfolio.
Clinical development and differentiation
TSLP antibody (045) demonstrates prolonged binding and high efficacy in early trials, with phase 2 data expected at end of 2026.
Ongoing placebo-controlled trial in moderate to severe atopic dermatitis aims to confirm differentiation.
Partner in China is running phase 3 studies in asthma and CRS with NP, and a phase 2 in COPD.
Study design includes dual dermatologist review to ensure accurate patient selection and minimize placebo effect.
Real moderate to severe AD patients are being enrolled to enhance trial integrity.
Bispecific antibody and strategic positioning
Bispecific TSLP/IL4R antibody shows greater potency than current standards in ex vivo assays.
Data from SAD/MAD in healthy volunteers expected first, followed by phase 1b in asthma and atopic dermatitis.
Both phase 1b studies are placebo-controlled, focusing on safety, PK, and efficacy endpoints.
Potential to address unmet needs in refractory diseases and expand into pediatric populations.
Strategic decision on advancing assets in AD will depend on comparative data and market needs.
Prioritize pipeline investment post-2026 readouts
Rationale for 2138's new lead indications
Bispecific vs TSLP MAB market positioning
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Next Aclaris Therapeutics earnings date
Q4 202526 Feb, 2026
Next Aclaris Therapeutics earnings date
Q4 202526 Feb, 2026
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Frequently asked questions
Aclaris Therapeutics Inc. is a clinical-stage biopharmaceutical company primarily engaged in the development of novel drug candidates for immuno-inflammatory diseases. Leveraging its core expertise in drug discovery, development, and kinase inhibition, Aclaris focuses on creating small molecule therapies for people affected by underserved immuno-inflammatory conditions. Its proprietary KINect® technology platform enables the development of clinical candidates targeting challenging kinases with novel approaches. Additionally, Aclaris operates Confluence Discovery Technologies, Inc., a full-service drug discovery and early development contract research organization. This subsidiary offers research partnership services across therapeutic areas and gene families, with expertise in a range of scientific disciplines including cell and molecular biology, biochemistry, enzymology, and immunology. he company is headquartered in Wayne, Pennsylvania, and its shares are listed on the Nasdaq.
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