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Aclaris Therapeutics (ACRS) investor relations material
Aclaris Therapeutics R&D Day 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.R&D Day 2025 summary14 Oct, 2025
Pipeline overview and program updates
Four clinical programs expected in 2026, including ATI-2138, Bosakitug (ATI-045), ATI-052, and next-gen ITK-selective inhibitors, with a diversified portfolio spanning oral and antibody assets targeting immunology and inflammation; additional multispecific antibodies are in preclinical development.
Lead assets include bispecific and ITK oral programs, both positioned as potential game changers in multiple large indications.
Early-stage portfolio highlighted by next-gen ITK inhibitors, with plans to expand into additional indications and maintain a robust data event calendar through 2027.
Integration of Biosion programs and team has strengthened clinical and organizational capabilities.
Clinical trial data and development milestones
ATI-2138 (ITK/JAK3 inhibitor) completed Phase 2a in atopic dermatitis with favorable safety and efficacy, advancing to Phase 2 in lichen planus in 1H 2026.
Bosakitug (ATI-045) is in a two-arm, placebo-controlled Phase 2 trial for moderate-to-severe atopic dermatitis, with results expected in 2H 2026; Phase 2a data showed high EASI-75 and IGA response rates.
ATI-052 (bispecific anti-TSLP/IL-4Ra) is in Phase 1a/1b SAD/MAD studies, with Phase 1b POC trials in asthma and atopic dermatitis planned for 2026.
Next-gen ITK inhibitors (ITK/TXK and ITK-selective) and bispecific antibodies are advancing toward IND submissions in 2026 and 2027, with preclinical data showing superior potency and selectivity.
R&D strategy and innovation priorities
Focus on developing best-in-class small and large molecules for immunology and inflammation, leveraging proprietary KINect platform for kinase inhibitor discovery.
Emphasis on multi-specific, dual, and trispecific antibodies and covalent kinase inhibitors to address complex immune-mediated diseases and raise efficacy ceilings.
State-of-the-art R&D capabilities in St. Louis enable deep profiling, translational research, and rapid progression from target inception to clinical proof of concept.
ITK's broad impact vs. biologics and JAK safety
ATI-052's clinical strategy to prove superior efficacy?
Impact of central photography on AD trial quality
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Next Aclaris Therapeutics earnings date
Q3 20255 Nov, 2025
Next Aclaris Therapeutics earnings date
Q3 20255 Nov, 2025
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Frequently asked questions
Aclaris Therapeutics Inc. is a clinical-stage biopharmaceutical company primarily engaged in the development of novel drug candidates for immuno-inflammatory diseases. Leveraging its core expertise in drug discovery, development, and kinase inhibition, Aclaris focuses on creating small molecule therapies for people affected by underserved immuno-inflammatory conditions. Its proprietary KINect® technology platform enables the development of clinical candidates targeting challenging kinases with novel approaches. Additionally, Aclaris operates Confluence Discovery Technologies, Inc., a full-service drug discovery and early development contract research organization. This subsidiary offers research partnership services across therapeutic areas and gene families, with expertise in a range of scientific disciplines including cell and molecular biology, biochemistry, enzymology, and immunology. he company is headquartered in Wayne, Pennsylvania, and its shares are listed on the Nasdaq.
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