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Acrivon Therapeutics (ACRV) investor relations material
Acrivon Therapeutics Q2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Executive summary
Advanced ACR-368 (Phase 2 for endometrial cancer) and ACR-2316 (Phase 1 for solid tumors), leveraging the AP3 platform for accelerated drug development.
ACR-368 OncoSignature test received FDA Breakthrough Device and Fast Track designations; Phase 2 trial showed 35% confirmed ORR and 80% tumor shrinkage in OncoSignature-positive endometrial cancer patients.
No revenue generated to date; operations funded by equity offerings, including a $123.8M PIPE in April 2024.
Cash, cash equivalents, and investments totaled $147.6M as of June 30, 2025, expected to fund operations into Q2 2027.
AP3 platform presented at AACR 2025, highlighting new cell cycle program and drug mechanism insights.
Financial highlights
Net loss of $21.0M for Q2 2025, up from $18.8M in Q2 2024; net loss of $40.7M for the six months ended June 30, 2025.
Research and development expenses were $16.2M in Q2 2025 (up $1.2M year-over-year) and $31.6M for the six months (up $5.1M year-over-year).
General and administrative expenses were $6.5M in Q2 2025 and $12.7M for the six months, both nearly flat year-over-year.
Interest income for Q2 2025 was $1.7M, down from $2.7M in Q2 2024.
Net cash used in operating activities was $36.1M for the six months ended June 30, 2025.
Outlook and guidance
Cash and investments expected to fund operations and capital expenditures into Q2 2027; additional funding needed for long-term plans.
Anticipates continued increases in R&D and G&A expenses as clinical programs advance and headcount grows.
Plans to provide clinical data updates for ACR-368 and ACR-2316 in H2 2025.
Advancement of a new cell cycle drug discovery program toward candidate nomination in 2025.
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