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Acrivon Therapeutics (ACRV) investor relations material

Acrivon Therapeutics Q2 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q2 2025 earnings summary13 Aug, 2025

Executive summary

  • Advanced ACR-368 (Phase 2 for endometrial cancer) and ACR-2316 (Phase 1 for solid tumors), leveraging the AP3 platform for accelerated drug development.

  • ACR-368 OncoSignature test received FDA Breakthrough Device and Fast Track designations; Phase 2 trial showed 35% confirmed ORR and 80% tumor shrinkage in OncoSignature-positive endometrial cancer patients.

  • No revenue generated to date; operations funded by equity offerings, including a $123.8M PIPE in April 2024.

  • Cash, cash equivalents, and investments totaled $147.6M as of June 30, 2025, expected to fund operations into Q2 2027.

  • AP3 platform presented at AACR 2025, highlighting new cell cycle program and drug mechanism insights.

Financial highlights

  • Net loss of $21.0M for Q2 2025, up from $18.8M in Q2 2024; net loss of $40.7M for the six months ended June 30, 2025.

  • Research and development expenses were $16.2M in Q2 2025 (up $1.2M year-over-year) and $31.6M for the six months (up $5.1M year-over-year).

  • General and administrative expenses were $6.5M in Q2 2025 and $12.7M for the six months, both nearly flat year-over-year.

  • Interest income for Q2 2025 was $1.7M, down from $2.7M in Q2 2024.

  • Net cash used in operating activities was $36.1M for the six months ended June 30, 2025.

Outlook and guidance

  • Cash and investments expected to fund operations and capital expenditures into Q2 2027; additional funding needed for long-term plans.

  • Anticipates continued increases in R&D and G&A expenses as clinical programs advance and headcount grows.

  • Plans to provide clinical data updates for ACR-368 and ACR-2316 in H2 2025.

  • Advancement of a new cell cycle drug discovery program toward candidate nomination in 2025.

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Frequently asked questions

Acrivon Therapeutics Inc is a clinical-stage biopharmaceutical company focused on developing precision oncology medicines. Utilizing its proprietary Acrivon Predictive Precision Proteomics (AP3) platform, the company advances drug candidates tailored to the predicted sensitivity of tumors to specific medicines. The company is headquartered in Watertown, Massachusetts, and its shares are listed on the NASDAQ.

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