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Acurx Pharmaceuticals (ACXP) investor relations material

Acurx Pharmaceuticals Q2 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q2 2025 earnings summary12 Aug, 2025

Executive summary

  • Announced a new Indian patent for DNA polymerase IIIC inhibitors, supporting preclinical antibiotic development for MRSA, VRE, DRSP, and anthrax, and published positive Phase 2b/2d ibezapolstat data in C. difficile infection.

  • Lead candidate ibezapolstat is advancing toward Phase 3 trials for C. difficile infection, with positive regulatory feedback from EMA and FDA.

  • No product revenue generated to date; operations funded through equity offerings, warrant inducements, and a $12M equity line of credit.

  • Implemented a 1-for-20 reverse stock split in August 2025 to maintain Nasdaq listing compliance.

  • Collaboration with Leiden University Medical Center presented new mechanism of action data for polymerase IIIC inhibitors at a major scientific conference.

Financial highlights

  • Ended Q2 2025 with $6.1M in cash, up from $3.7M at year-end 2024; working capital was $3.6M.

  • Q2 2025 net loss was $2.2M ($1.89/share), improved from $4.1M ($5.21/share) in Q2 2024; six-month net loss was $4.4M ($4.01/share), down from $8.5M ($10.84/share) year-over-year.

  • R&D expenses for Q2 2025 were $0.5M, down from $1.8M in Q2 2024; G&A expenses were $1.7M, down from $2.3M.

  • Raised $3.4M in Q2 2025 through equity and warrant transactions; net cash provided by financing activities for H1 2025 was $6.1M.

  • Accumulated deficit reached $71.7M as of June 30, 2025.

Outlook and guidance

  • Current cash resources are not sufficient for at least 12 months; additional financing is required.

  • Ongoing multi-step capital raising strategy includes financings, warrant inducements, and public-private partnerships.

  • Cash burn rate reduced to ~$400K/month, with expectations to maintain this trend.

  • Preparing to initiate international Phase 3 trials for ibezapolstat, pending financing.

  • Partnership discussions, including with government agencies, are ongoing and may extend into 2026.

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Frequently asked questions

Acurx Pharmaceuticals Inc. is a clinical-stage biopharmaceutical company focused on developing antibiotic treatments for bacterial infections. The company's research and development efforts are primarily centered on addressing antibiotic resistance, targeting bacterial pathogens that pose a significant threat to public health. Acurx utilizes a novel approach to inhibit bacterial DNA synthesis, working to combat infections that are increasingly resistant to traditional antibiotics. Its pipeline includes various antibiotic candidates aimed at providing new therapeutic options for patients. The company is headquartered in Staten Island, New York, and its shares are listed on the NASDAQ.

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