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Adlai Nortye (ANL) investor relations material
Adlai Nortye Corporate Presentation summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Pipeline and research overview
Advancing first-in-class and best-in-class preclinical assets, including AN8025 and AN9025, with IND filings expected in 2025.
Global R&D and clinical operations span the U.S. and China, supporting a robust oncology pipeline.
Pipeline includes multi-functional T cell/APC modulators, pan-RAS inhibitors, and oral PD-L1 inhibitors targeting advanced solid tumors.
Multiple assets are progressing through clinical and preclinical stages, with key data readouts and updates anticipated by year-end 2025.
AN8025: Multi-functional T cell/APC modulator
AN8025 targets PD-L1, Lag3v, and CD86v, activating APCs and reactivating T cells for anti-tumor immunity.
Demonstrates superior T-cell activation and tumor cell killing compared to existing checkpoint inhibitors.
Shows potent anti-tumor activity in vivo and favorable PK/safety in non-human primates.
IND filing expected mid-2025, with multiple registrational trials planned.
AN9025: Oral pan-RAS (ON) inhibitor
AN9025 exhibits strong, sustained binding to CypA and RAS (ON) proteins, outperforming RMC-6236 in potency and duration.
Achieves deeper tumor regression and more durable RAS pathway inhibition in preclinical models.
Demonstrates approximately 100-fold greater potency in RAS mutant cell lines versus RMC-6236.
IND filing targeted for 2H 2025.
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