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Kalaris Therapeutics (KLRS) investor relations material
Kalaris Therapeutics Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Executive summary
Focused on developing TH103, a novel anti-VEGF drug for retinal diseases, with ongoing Phase 1a and 1b/2 clinical trials in neovascular AMD and plans to expand into DME and RVO.
Initiated enrollment for Phase 1b/2 multiple ascending dose trial of TH103 in nAMD; Phase 1a single ascending dose trial remains on track for initial data by year end 2025.
No products approved or revenue generated; operations funded by equity, convertible notes, and $102.1M in cash from a merger with AlloVir.
Merger with AlloVir in March 2025 resulted in a reverse recapitalization, with Legacy Kalaris shareholders owning 74.47% of the combined company.
Entered agreement with KBI Biopharma for clinical supply manufacturing; opened new headquarters and hired a new CFO.
Financial highlights
Cash, cash equivalents, and short-term investments totaled $77.0M as of September 30, 2025, up from $1.6M at December 31, 2024, primarily due to the merger with AlloVir.
Net loss for Q3 2025 was $11.9M, compared to $38.1M in Q3 2024; net loss for the nine months ended September 30, 2025 was $33.4M, down from $47.1M in the prior year period.
Research and development expenses for the nine months ended September 30, 2025 were $23.6M, down from $41.2M year-over-year, primarily due to a $32.1M one-time royalty obligation expense in 2024.
General and administrative expenses increased to $11.8M for the nine months ended September 30, 2025, up from $3.4M year-over-year, mainly due to higher legal, accounting, insurance, and personnel costs post-merger.
No revenue recognized; all funding from financing activities.
Outlook and guidance
Cash runway expected to fund operations into 2027 based on current plans.
Initial clinical data from the Phase 1a trial of TH103 expected by year-end 2025; Phase 1b/2 data expected in the second half of 2026.
Anticipates continued operating losses and need for additional capital to advance development and commercialization.
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