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Altimmune (ALT) investor relations material
Altimmune H.C. Wainwright Liver Disease Virtual Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H.C. Wainwright Liver Disease Virtual Conference summary21 Oct, 2025
Conference overview
The event combined viral hepatitis, MASH, and liver cancer topics, featuring leading biotech firms and key opinion leaders.
Focus was on innovative therapies for liver diseases, especially MASH and hepatocellular carcinoma.
Pemvidutide mechanism and clinical data
Pemvidutide is a dual GLP-1/glucagon receptor agonist targeting both metabolic and hepatic aspects of MASH.
24-week phase IIb IMPACT trial showed robust weight loss, liver fat reduction, and significant biomarker improvements.
Achieved 59% MASH resolution at 24 weeks, outperforming or matching other compounds at longer durations.
Non-invasive markers (CT1, ELF, VCTE) and AI-based biopsy readings showed strong anti-inflammatory and anti-fibrotic effects.
Class-leading reductions in serum ALT and normalization of liver fat in about 50% of subjects.
Regulatory and trial design strategy
48-week IMPACT data and end of phase II FDA meeting are scheduled for Q4, with phase III planned for 2026.
Trial design is flexible to adapt to potential regulatory shifts from biopsy to non-invasive tests as primary endpoints.
Objectives for the FDA meeting include confirming trial design, safety database, and clarity on NITs versus biopsy endpoints.
What 48-week data would be most compelling?
How will FDA's NITs view shape Phase 3 design?
Pemvidutide's edge in a consolidating NASH market?
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Next Altimmune earnings date
Q3 20256 Nov, 2025
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Frequently asked questions
Altimmune, Inc. engages in the development of immunotherapeutics for infectious and chronic diseases. The company focuses on the development of vaccines and therapeutics for influenza, anthrax and COVID-19. It offers HepTcell, a vaccine candidate to treat Chronic Hepatitis B; AdCOVID, which is an intranasal antigen vaccine to fight COVID-19; NasoVAX, a single dose flu vaccine; T-COVID, an intranasal immune modulating therapeutic candidate; and NasoShield, an anthrax vaccine product candidate. The company was founded by Vipin K. Garg on April 15, 2005 and is headquartered in Gaithersburg, MD.
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