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Annexon (ANNX) investor relations material
Annexon Cantor Global Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Cantor Global Healthcare Conference 2025 summary4 Sep, 2025
Company overview and therapeutic strategy
Focuses on the classical complement pathway, targeting the most upstream aspect (C1q) to address inflammatory diseases in the body, brain, and eye.
All programs are first-in-kind or pioneering, with consistent positive outcomes across flagship programs.
Three main programs: Guillain-Barré syndrome (GBS, most advanced), geographic atrophy (GA), and ANX-1502, a first-in-kind small molecule.
Clinical development and trial outcomes
GBS program completed a robust Phase III study ex-US, showing 90% of patients improved by week one, with significant reductions in ICU and ventilator time.
Shorter complement inhibition (30mg/kg) outperformed longer inhibition (75mg/kg), supporting limited inhibition for optimal recovery.
Real world evidence (RWE) study matched Phase III patients to a large natural history dataset, showing superior outcomes to IVIG on all key measures.
Regulatory and approval pathway
EMA and FDA require substantial Phase III evidence and demonstration of generalizability via RWE.
EMA has agreed on adequacy of studies and comparability analysis; rapporteur assigned and local meetings productive.
FDA discussions ongoing, with focus on generalizability policy for ex-US data; further meetings planned to clarify requirements.
Clarify FDA's policy on ex-U.S. study data
ANX1502 food effect: How will this be addressed?
What differentiates vonaprument in GA market?
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Next Annexon earnings date
Q3 202514 Nov, 2025
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Frequently asked questions
Annexon, Inc. is a clinical-stage biopharmaceutical company engaged in discovering and developing therapeutics for autoimmune, neurodegenerative, and ophthalmic disorders. The company focuses on targeting C1q, an initiating molecule of the classical complement pathway, which plays a critical role in various disease processes, including antibody-mediated autoimmune diseases and complement-mediated neurodegeneration. Annexon's pipeline includes several product candidates such as ANX005, which is in clinical trials for Guillain-Barré syndrome, and other trials for warm autoimmune hemolytic anemia, Huntington's disease, and amyotrophic lateral sclerosis. Annexon is headquartered in Brisbane, California, and its shares are listed on the Nasdaq.
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