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Aprea Therapeutics (APRE) investor relations material
Aprea Therapeutics Registration filing summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Company overview and business model
Clinical-stage precision medicine oncology company developing targeted therapies for biomarker-defined cancers using synthetic lethality approaches.
Pipeline includes WEE1 inhibitor (APR-1051), ATR inhibitor (ATRN-119), and early-stage DYRK1A/B inhibitor (APR-1602).
Focus on matching treatments to specific genetic mutations to maximize effectiveness and minimize side effects.
Shifted focus to assets acquired from Atrin Pharmaceuticals and in-house developments after May 2022 acquisition.
Financial performance and metrics
Audited financials for 2024 and 2025 include an explanatory paragraph about substantial doubt regarding ability to continue as a going concern.
As of March 31, 2026, 11,982,776 shares of common stock were outstanding.
Use of proceeds and capital allocation
No proceeds from resale of shares by selling stockholders; proceeds from warrant exercises, if any, will be used for clinical trials, working capital, and general corporate purposes.
Actual expenditures will depend on clinical trial progress and operational cash needs; management retains broad discretion over use of funds.
- APR-1051 demonstrates early efficacy and safety as a selective WEE1 inhibitor in targeted cancers.APRE
Corporate presentation20 Apr 2026 - Key votes include director elections, a reverse stock split, and executive compensation approval.APRE
Proxy filing20 Apr 2026 - Shelf registration filed amid auditor's going concern warning and strong scientific leadership.APRE
Registration Filing17 Mar 2026 - Clinical progress and improved financials position the company for key milestones in 2026.APRE
Q4 202516 Mar 2026 - Promising early data for a daily WEE1 inhibitor show efficacy and safety in targeted cancer patients.APRE
Oppenheimer 36th Annual Healthcare Life Sciences Conference26 Feb 2026 - Registering 12.6M shares for resale, with proceeds from warrants funding clinical trials amid financial risk.APRE
Registration Filing20 Feb 2026 - APR-1051 demonstrates potent, selective WEE1 inhibition with a differentiated safety profile in early trials.APRE
Study Update3 Feb 2026 - Ongoing trials for WEE1 and ATR inhibitors show early efficacy, with major updates due by early 2025.APRE
H.C. Wainwright 27th Annual Global Investment Conference31 Dec 2025 - Registering 5.5M shares for resale, with major dilution and financial risks highlighted.APRE
Registration Filing19 Dec 2025
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