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Investor Relations14 Oct 2025
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Aprea Therapeutics (APRE) investor relations material
Aprea Therapeutics H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H.C. Wainwright 27th Annual Global Investment Conference summary9 Sep, 2025
Pipeline overview and strategic focus
Focused on precision medicine and synthetic lethality, targeting genetic mutations in cancer.
Pipeline includes ATR inhibitor, WE-one inhibitor (APR-1051), legacy p53 reactivator, and an undisclosed target to be revealed later in the year.
Strong emphasis on intellectual property protection for all programs.
Management and board have extensive drug development experience.
Clinical progress and trial updates
IND for WE-one inhibitor filed and cleared in 2024; first patient enrolled and dose escalation ongoing.
Dose escalation for WE-one increased beyond initial projections due to positive safety data, expanding therapeutic index.
Early signs of activity and stable disease observed in lower dose cohorts.
ATR inhibitor program adjusted to BID regimen due to pharmacokinetics, with ongoing dose escalation.
Translational and biomarker-driven approach
Preclinical models show strong translation to clinical settings, with biomarker-driven patient selection.
Notable patient cases demonstrate improved responses and stable disease in heavily pretreated populations.
Collaboration with MD Anderson supports biomarker research, especially in HPV-positive head and neck cancer.
Combination therapy studies show synergistic effects and maintained efficacy at reduced doses.
What is the impact of increased WE-one MTD?
What's next for ATR dosing optimization?
When will undisclosed target be revealed?
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Next Aprea Therapeutics earnings date
Q3 20256 Nov, 2025
Next Aprea Therapeutics earnings date
Q3 20256 Nov, 2025
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Eferix Drawings Google Play
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Frequently asked questions
Aprea Therapeutics Inc. is a biopharmaceutical company focused on developing cancer treatments. The company specializes in small-molecule therapies that target tumor suppressor pathways to address various malignancies. Its research and development efforts aim to enhance the effectiveness of existing treatments and explore novel therapeutic approaches. The company is headquartered in Doylestown, Pennsylvania, and its shares are listed on the NASDAQ.
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