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Aprea Therapeutics (APRE) investor relations material
Aprea Therapeutics Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q3 2025 earnings summary12 Nov, 2025
Executive summary
Focused on precision oncology with lead programs APR-1051 (WEE1 inhibitor) and ATRN-119 (ATR inhibitor), both in early clinical development and showing promising early efficacy in heavily pretreated cancer patients.
APR-1051 Phase 1 dose escalation ongoing, with data expected in Q1 2026; 3 of 4 patients at 100 mg achieved stable disease and safety profile is manageable.
ATRN-119 monotherapy enrollment paused after enrolling 43 patients to explore combination strategies; recommended Phase 2 dose set at 1,100 mg.
Pipeline includes preclinical DDR-targeting programs; no commercial products or product revenue expected in the near term.
Posters on APR-1051 and ATRN-119 presented at a major international oncology conference in October 2025.
Financial highlights
Cash and cash equivalents at September 30, 2025: $13.7 million, down from $22.8 million at December 31, 2024.
Net loss for Q3 2025: $3.0 million ($0.47 per share), improved from $3.8 million ($0.64 per share) in Q3 2024.
Net loss for the nine months ended September 30, 2025: $10.1 million, similar to the prior year period.
R&D expenses decreased to $1.6 million in Q3 2025 from $2.8 million in Q3 2024; for the nine months ended September 30, 2025, R&D expenses were $6.0 million.
G&A expenses for Q3 2025 were $1.5 million, slightly down from $1.6 million in Q3 2024; for the nine months ended September 30, 2025: $4.8 million, down from $5.4 million year-over-year.
Outlook and guidance
Cash position expected to fund operations and capital expenditures into Q4 2026, but substantial doubt exists about ability to continue as a going concern without additional funding.
Actively seeking additional funding; may need to reduce expenditures or curtail development if financing is not secured.
Anticipates value-creating clinical catalysts in 2026, including potential combination studies for both lead assets.
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Next Aprea Therapeutics earnings date
Q4 202527 Mar, 2026
Next Aprea Therapeutics earnings date
Q4 202527 Mar, 2026
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Frequently asked questions
Aprea Therapeutics Inc. is a biopharmaceutical company focused on developing cancer treatments. The company specializes in small-molecule therapies that target tumor suppressor pathways to address various malignancies. Its research and development efforts aim to enhance the effectiveness of existing treatments and explore novel therapeutic approaches. The company is headquartered in Doylestown, Pennsylvania, and its shares are listed on the NASDAQ.
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