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Aptose Biosciences (APTO) investor relations material
Aptose Biosciences Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q3 2025 earnings summary13 Nov, 2025
Executive summary
Tuspetinib-based triple drug therapy for AML demonstrated excellent safety and 100% CR/CRh response rates at 80 mg and 120 mg, with dose escalation to 160 mg underway and data presented at major hematology conferences.
Luxeptinib development paused due to funding prioritization, with alternative paths or collaborations being explored.
APTO-253 development discontinued.
Financial highlights
Net loss for Q3 2025 was $5.1 million, down from $7.0 million in Q3 2024; net loss for the nine months ended September 30, 2025 was $17.7 million, down from $23.8 million in the prior year period.
Cash, cash equivalents, and restricted cash as of September 30, 2025 totaled $1.6 million, down from $6.7 million at December 31, 2024.
Operating expenses for Q3 2025 were $4.9 million, down from $7.0 million in Q3 2024.
Shareholders' deficit increased to $19.5 million from $4.5 million at year-end 2024.
Research and development expenses for the nine months ended September 30, 2025 were $7.9 million, down from $15.6 million in the prior year period.
Outlook and guidance
Negative cash flows are expected to continue until regulatory approval or milestone revenues are achieved.
Additional financing is necessary to fund operations; management is considering debt, collaborations, or reorganization.
Ongoing dose escalation in the TUSCANY trial, with 160 mg cohort underway and further data to be presented at ASH in December 2025.
Substantial doubt exists about the ability to continue as a going concern without significant restructuring or financing.
TUSCANY durability and unadjusted VEN+AZA dosing
What is the current cash runway without Hanmi advances?
Rationale for R&D program prioritization and cuts?
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Next Aptose Biosciences earnings date
The 67th American Society of Hematology (ASH) Annual Meeting6 Dec, 2025
Next Aptose Biosciences earnings date
The 67th American Society of Hematology (ASH) Annual Meeting6 Dec, 2025
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Frequently asked questions
Aptose Biosciences Inc. is a clinical-stage biotechnology company focused on developing targeted therapies for hematologic malignancies, including leukemia, lymphoma, and myeloma. The company leverages innovative approaches in small-molecule drug design to address unmet medical needs in cancer treatment. The company is headquartered in Toronto, Canada, and its shares are listed on the NASDAQ.
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