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Arcturus Therapeutics (ARCT) investor relations material
Arcturus Therapeutics Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q3 2025 earnings summary10 Nov, 2025
Executive summary
Advanced ARCT-032 (CF mRNA therapy) with positive interim Phase 2 data showing safety and mucus plug reduction in class one CF adults; 15mg cohort ongoing, 12-week study planned for 2026.
ARCT-810 (OTC deficiency mRNA therapy) progressing toward pivotal trial discussions with regulators in 2026 for both pediatric and adult populations.
Achieved commercial sales of the world's first approved self-amplifying mRNA (sa-mRNA) vaccine, KOSTAIVE, in Japan and received European approval for KOSTAIVE (ARCT-154) for adults 18+ in February 2025.
KOSTAIVE US BLA filing delayed indefinitely due to regulatory changes; commercial focus shifts to Asia and Europe.
Strong cash position and extended runway into 2028 following cost reductions and delayed trial starts.
Financial highlights
Q3 2025 revenue was $17.2M, down $24.5M year-over-year; nine-month revenue was $74.8M, down $54.7M year-over-year, mainly due to lower CSL collaboration revenue.
Q3 operating expenses were $33.7M, down from $52.4M last year; nine-month operating expenses were $119.8M, down from $191.8M.
R&D expenses for Q3 were $23.3M, down from $39.1M; nine-month R&D was $87.7M, down from $151.4M.
Net loss for Q3 was $13.5M ($0.49/share), compared to $6.9M ($0.26/share) last year.
Cash and equivalents were $237.3M as of September 30, 2025.
Outlook and guidance
12-week ARCT-032 CF study to begin in 2026, with expanded global enrollment and additional sites outside the US.
Regulatory meetings for ARCT-810 pivotal trial design expected in the first half of 2026.
General and administrative expenses expected to decrease slightly in fiscal 2026.
Cash runway guidance includes global trial expansion and is expected to last into 2028.
Future capital needs will depend on regulatory approvals, milestone achievements, and commercialization success.
What endpoints drive ARCT-032's Phase III decision?
ARCT-810: OTC adult vs. pediatric trial strategy
Primary factors extending cash runway into 2028
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Next Arcturus Therapeutics earnings date
Q4 20255 Mar, 2026
Next Arcturus Therapeutics earnings date
Q4 20255 Mar, 2026
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Frequently asked questions
Arcturus Therapeutics Holdings Inc. is a biotechnology company focused on developing RNA-based therapeutics for the treatment of infectious diseases, rare diseases, and other medical conditions. The company utilizes its proprietary self-amplifying mRNA technology and lipid nanoparticle delivery system to develop vaccines and therapies. Arcturus' pipeline includes treatments for diseases such as COVID-19 and other RNA-based therapies targeting unmet medical needs. The company is headquartered in San Diego, California, and its shares are listed on the NASDAQ.
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