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Candel Therapeutics (CADL) investor relations material
Candel Therapeutics H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H.C. Wainwright 27th Annual Global Investment Conference summary5 Sep, 2025
Key clinical developments
CAN-2409 achieved primary endpoint of disease-free survival in a Phase 3 trial for prostate cancer, with a 30% improvement and strong statistical significance.
Secondary endpoints showed a 38% improvement in prostate cancer-specific disease-free survival and an 80.4% pathological complete response rate at two years.
CAN-2409 demonstrated significant survival benefits in borderline resectable pancreatic cancer and therapy-resistant non-small cell lung cancer.
CAN-3110, a novel oncolytic HSV-1 virus, showed promising results in recurrent high-grade glioma, with new data on repeated injections expected by Q4.
Both investigational medicines received Fast Track and Orphan Drug designations, with RMAT designation for CAN-2409 in prostate cancer.
Regulatory and commercialization progress
BLA submission for CAN-2409 in prostate cancer is planned for Q4 next year, with manufacturing scale-up and product stability underway.
Engaged with FDA and EMA, securing SPA agreement and orphan designation in Europe for pancreatic cancer.
Pre-commercialization activities are ongoing, including engagement with payers, healthcare professionals, and patients.
Protocols for Phase 3 trials in non-small cell lung cancer and Phase 2B/3 in pancreatic cancer are being finalized, with trial initiation contingent on non-dilutive funding.
Financial and organizational highlights
Over $100 million in cash with a runway into Q1 2027.
Strong executive team and high-profile Research Advisory Board, including Nobel laureate Jim Allison.
Robust IP protection and data exclusivity for both CAN-2409 and CAN-3110.
RMAT: How does it accelerate CAN-2409 approval?
CAN-2409: Non-dilutive funding strategy
CAN-3110: Timeline for NESTIN tumor expansion
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Next Candel Therapeutics earnings date
Q3 202513 Nov, 2025
Next Candel Therapeutics earnings date
Q3 202513 Nov, 2025
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Frequently asked questions
Candel Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing viral immunotherapies for cancer treatment. The company’s approach involves using genetically modified viruses to induce immunogenic cell death in cancer cells, which unmask tumor antigens within an activated microenvironment. This process triggers a systemic and durable immune response against tumors, acting as an in situ vaccination. Candel’s therapies are designed to potentially improve survival rates and maintain the quality of life for patients across various stages of cancer. The company is headquartered in Needham, Massachusetts, and its shares are listed on NASDAQ.
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