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Cardiff Oncology (CRDF) investor relations material
Cardiff Oncology Piper Sandler 37th Annual Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Piper Sandler 37th Annual Healthcare Conference summary2 Dec, 2025
PLK1 biology and therapeutic rationale
PLK1 is a serine-threonine kinase essential for cell division and is overexpressed in tumor cells, driving metastasis and dependency.
PLK1 promotes DNA repair and angiogenesis, contributing to tumor growth and resistance.
Onvansertib characteristics and clinical development
Onvansertib is a highly selective, oral PLK1 inhibitor with a short half-life, enabling better tolerability and combination with chemotherapies.
Demonstrated 5,000-fold selectivity for PLK1 over related kinases, reducing off-target toxicity.
Phase II CRDF-004 study showed dose-dependent improvements in efficacy, including a 19% higher confirmed objective response rate at 30 mg compared to standard of care.
No significant increase in toxicity when combined with FOLFOX or FOLFIRI plus Avastin.
Forward-looking plans and financial position
Planning to update durability data (PFS and duration of response) in Q1 next year.
Aiming for FDA alignment on phase III trial design, targeting both accelerated and full approval endpoints.
Exploring additional indications, including triple-negative breast cancer and small cell lung cancer, based on preclinical and early clinical data.
Ended Q3 with over $60 million in cash, providing runway through Q1 2027 and supporting upcoming milestones.
Additional funding will be required to initiate and run the phase III trial.
FDA alignment on Phase 3 accelerated approval
Plan for Phase 3 trial funding
Prioritize next indications for Onvansertib
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Next Cardiff Oncology earnings date
Sidoti's Year End Virtual Investor Conference11 Dec, 2025
Next Cardiff Oncology earnings date
Sidoti's Year End Virtual Investor Conference11 Dec, 2025
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Frequently asked questions
Cardiff Oncology Inc. is a clinical-stage biotechnology company based in San Diego, California, focused on developing innovative therapies for various cancers. The company's primary approach involves leveraging PLK1 (Polo-like Kinase 1) inhibition to create novel cancer treatments. Their flagship product, onvansertib, is an oral selective PLK1 inhibitor currently being evaluated in combination with standard-of-care therapeutics across several clinical programs. These include treatments for KRAS-mutated metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma, and metastatic castrate-resistant prostate cancer. The company is headquartered in San Diego, California, and its shares are listed on the Nasdaq.
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