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Caribou Biosciences (CRBU) investor relations material
Caribou Biosciences Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q3 2025 earnings summary12 Nov, 2025
Executive summary
Positive phase 1 data for vispa-cel in LBCL and CB-011 in multiple myeloma highlight efficacy and safety, supporting potential best-in-class allogeneic CAR-T therapies.
Both programs show durable responses and manageable safety, enabling outpatient administration and broader patient access.
Financial highlights
Licensing and collaboration revenue was $2.2 million for Q3 2025, up from $2.0 million in Q3 2024.
R&D expenses decreased to $22.4 million from $30.4 million year-over-year, mainly due to reduced clinical trial activities and workforce reduction.
G&A expenses fell to $9.2 million from $9.8 million year-over-year, reflecting lower personnel costs.
Net loss for Q3 2025 was $27.5 million, compared to $33.6 million in Q3 2024.
Cash, cash equivalents, and marketable securities totaled $159.2 million as of September 30, 2025, down from $249.4 million at year-end 2024.
Outlook and guidance
Cash reserves are expected to fund operations, including CB-011 dose expansion and vispa-cel pivotal trial start-up, into 2H 2027.
Plans to advance vispa-cel to a pivotal phase 3 trial in 2L LBCL CD19-naive patients, with design refinement ongoing with the FDA.
CB-011 dose expansion to begin by year-end, with further data expected in 2026.
Detail vispa-cel pivotal trial funding strategy
How does vispa-cel enable outpatient administration?
Detail CB-011's immune cloaking mechanism
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Next Caribou Biosciences earnings date
Evercore ISI 8th Annual HealthCONx Conference2 Dec, 2025
Next Caribou Biosciences earnings date
Evercore ISI 8th Annual HealthCONx Conference2 Dec, 2025
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Frequently asked questions
Caribou Biosciences Inc. is a clinical-stage biopharmaceutical company at the forefront of genome editing technology. It focuses on developing genome-edited allogeneic cell therapies for the treatment of cancer and other devastating diseases. The company utilizes CRISPR-Cas9 technology to create precise, directed changes in the DNA of living cells, aiming to develop innovative therapies that can address unmet medical needs. Caribou's leading product candidates include allogeneic chimeric antigen receptor T (CAR-T) cell therapies for hematologic malignancies and solid tumors. This approach allows for the development of therapies that are not patient-specific but can be used as "off-the-shelf" treatments, potentially reducing time and cost compared to traditional autologous CAR-T therapies. The company is headquartered in Berkeley, CA, and its shares are listed on the NASDAQ.
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