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Centessa Pharmaceuticals (CNTA) investor relations material
Centessa Pharmaceuticals Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Evercore ISI 8th Annual HealthCONx Conference summary3 Dec, 2025
Strategic focus and pipeline development
Doubling down on orexin biology and agonism, a validated target in neurosciences.
ORX750 Phase II study shows robust efficacy in Narcolepsy type 1, type 2, and idiopathic hypersomnia (IH).
ORX142 and ORX489, both potent and selective for orexin 2, are entering Phase I with patient studies planned for Q1 2026.
Multiple assets in the orexin agonist franchise target broader neurodegenerative and psychiatric disorders.
No key liabilities identified among the three main assets, each positioned for different markets and indications.
Clinical trial updates and data insights
Phase II study expanded to 96 patients, with ongoing dose optimization to determine the optimal dose for registrational studies.
Minimum cohort sizes: 10 NT1, 12 NT2, 12 IH per fixed dose, but actual enrollment can exceed these numbers.
As of September 23, 17 IH patients enrolled at 2 mg dose; 50 new patients are currently being dosed at higher levels.
Efficacy data: NT1 showed >20 min MWT improvement, half above 30 min; NT2 showed >10 min change from baseline, placebo-adjusted.
Safety data across 55 patients revealed only three mild, transient visual disturbances, with no dose response observed.
Market and competitive landscape
Orexin agonists are seen as a major category, with strong physician and PI enthusiasm, especially after recent NT2 data.
Differentiation among orexin agonists is emerging as more data becomes available.
Mechanism of action extends beyond narcolepsy, with potential in cognition, executive function, mood, fatigue, and other neuropsychiatric symptoms.
Orexin agonists could impact conditions like ADHD, major depressive disorder, and Parkinson's, leveraging a broad neurotransmitter cascade.
No current plans to disclose specific indications for new assets due to competitive considerations.
What specific data from higher ORX750 doses will further differentiate its profile?
How will Centessa select ORX142/489 indications?
How does ORX750's visual AE profile impact its therapeutic index?
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Next Centessa Pharmaceuticals earnings date
Q4 202524 Mar, 2026
Next Centessa Pharmaceuticals earnings date
Q4 202524 Mar, 2026
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Frequently asked questions
Centessa Pharmaceuticals plc is a clinical-stage pharmaceutical company dedicated to discovering, developing, and delivering transformative medicines. Established in 2020, the company focuses on developing a wide range of innovative treatments across various therapeutic areas, including rare diseases and immuno-oncology. Centessa Pharmaceuticals is headquartered in Altrincham, United Kingdom, and its shares are listed on the NASDAQ.
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