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Chemomab Therapeutics
Chemomab Therapeutics (CCMB) investor relations material
Chemomab Therapeutics Oppenheimer 36th Annual Healthcare Life Sciences Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Oppenheimer 36th Annual Healthcare Life Sciences Conference summary26 Feb, 2026
Company overview and lead asset
Focuses on developing novel treatments for inflammatory and fibrotic diseases, with nebokitug as the lead monoclonal antibody targeting CCL24.
Nebokitug has shown strong anti-inflammatory and anti-fibrotic effects in preclinical and clinical studies across liver, skin, and lung.
Target indications include primary sclerosing cholangitis (PSC) and systemic sclerosis (SSc), both rare diseases with high unmet need.
Nebokitug holds Orphan Drug Designation from both EMA and FDA for PSC.
Clinical trial results and development plans
Phase II study in PSC demonstrated safety, tolerability, and significant improvements in inflammatory and fibrotic biomarkers, especially in moderate to advanced disease.
The 20 mg/kg dose is selected for phase III, focusing on patients with moderate to advanced PSC.
After 48 weeks, patients showed continued biomarker improvement and an 80% reduction in clinical events compared to historical controls.
Phase III will use clinical events as the primary endpoint, with potential for interim analysis and early BLA filing.
Approximately 50% of PSC patients have moderate to advanced disease, the main target for phase III, but broader applicability is anticipated.
Market opportunity and competitive landscape
PSC market estimated at over $1 billion in revenues, with potential to expand as new therapies become available.
Nebokitug is positioned as the only late-stage disease-modifying therapy in PSC, targeting both inflammation and fibrosis.
Systemic sclerosis represents a $1.5 billion market with no current disease-modifying drugs.
Nebokitug's dual mechanism offers potential across multiple fibrotic and inflammatory indications.
PSC market penetration strategy for nebokitug
Partner views on PSC Phase 3 clinical event endpoint
SSc trial design: broad SSc vs. SSc-ILD focus
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Next Chemomab Therapeutics earnings date
Q4 202513 Mar, 2026
Chemomab Therapeutics
Next Chemomab Therapeutics earnings date
Q4 202513 Mar, 2026
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Frequently asked questions
Chemomab Therapeutics Ltd is an Israel-based clinical-stage biotechnology company focused on the development of therapies for fibrotic and inflammatory diseases. The company’s lead drug candidate is based on targeting CCL24, a chemokine involved in fibrosis and inflammation. Chemomab's pipeline includes treatments for conditions such as primary sclerosing cholangitis (PSC) and systemic sclerosis. The company conducts preclinical and clinical studies and collaborates with research institutions to advance its drug development efforts. Chemomab Therapeutics Ltd is headquartered in Tel Aviv, Israel, and its shares are listed on the NASDAQ.
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