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Cogent Biosciences (COGT) investor relations material
Cogent Biosciences Citi's Biopharma Back to School Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Citi's Biopharma Back to School Conference summary3 Sep, 2025
Company mission and pipeline
Focus on developing targeted therapies for rare genetically driven diseases, with lead asset bezuclastinib targeting KIT mutations.
Pivotal studies underway in nonadvanced and advanced systemic mastocytosis and gastrointestinal stromal tumors (GIST).
Recent positive data from the SUMMIT trial in nonadvanced systemic mastocytosis, with FDA submission planned for 2026.
Additional early-stage programs in FGFR, Erb2, PI3K, and KRAS targets are in development.
Scientific rationale and drug differentiation
Bezuclastinib is designed for high potency and selectivity, avoiding off-target effects common in other KIT inhibitors.
Unlike avapritinib, bezuclastinib is not CNS penetrant and spares other class III RTKs, reducing side effects.
Selectivity profile aims to minimize adverse events while maximizing efficacy in KIT-driven diseases.
Disease landscape and patient needs
Systemic mastocytosis is divided into advanced (mortality risk) and nonadvanced (morbidity, significant symptoms) forms, both driven by KIT D816V mutation.
Nonadvanced patients often face delayed diagnosis and struggle with skin symptoms, fatigue, CNS issues, and risk of anaphylaxis.
Patients seek therapies that address the root cause rather than just symptom management.
Impact of SM-AHN concurrent treatment on market
How bezuclastinib safety enables full symptom resolution
GIST combo strategy: Frontline potential or market lead
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Next Cogent Biosciences earnings date
Q3 202511 Nov, 2025
Next Cogent Biosciences earnings date
Q3 202511 Nov, 2025
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Frequently asked questions
Cogent Biosciences Inc. is a biotechnology company focused on the development of precision therapies for genetically defined diseases. The company's lead product, bezuclastinib (CGT9486), is a selective tyrosine kinase inhibitor targeting mutations in the KIT receptor tyrosine kinase. These mutations are critical in conditions such as systemic mastocytosis and advanced gastrointestinal stromal tumors. Cogent Biosciences holds a licensing agreement with Plexxikon Inc. for the research, development, and commercialization of bezuclastinib. The company is headquartered in Waltham, Massachusetts, and its shares are listed on the Nasdaq.
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