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Compass Therapeutics (CMPX) investor relations material
Compass Therapeutics Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Evercore ISI 8th Annual HealthCONx Conference summary4 Dec, 2025
Pipeline and clinical progress
Four oncology drugs in development: three in clinic, one entering trials early next year.
Lead program Tevesemig (DLL4 VEGF-A bispecific) to report PFS and OS secondary endpoints in Q1 2026.
PD-1, PD-L1 bispecific antibody showed three responses in first 15 patients, including refractory cases.
Cohort expansions planned for triple-negative breast cancer and non-small cell lung cancer, with data readout and scientific presentation in the coming year.
Novel PD-1 VEGF-A bispecific entering clinic early next year; CD137 agonist to start biomarker-driven basket study in first half of next year.
Clinical data and efficacy insights
Tevesemig more than tripled response rate over control in randomized BTC study; lower progressive disease incidence in combination arm.
Early separation of PFS curves observed; fewer deaths than projected, suggesting improved OS.
Formation of a tail on the Kaplan-Meier curve indicates potential long-term survival benefit.
Median PFS in single-arm phase 2 BTC study was 9.4 months, with lower bound at 5.4 months.
Three confirmed responses in phase 1 PD-1, PD-L1 bispecific, including near CR in NSCLC and durable response in refractory TNBC.
Market opportunity and commercial strategy
U.S. annual BTC incidence estimated at 25,000, with 15,000 reaching second-line therapy.
Six months median duration on drug could yield a multi-billion-dollar opportunity in BTC alone.
Frontline BTC study ongoing at MD Anderson; expansion to other DLL4-expressing tumors like colorectal, hepatocellular, and ovarian considered.
Commercial-ready manufacturing process established for Tevesemig; pre-commercial work and prescriber awareness initiatives underway.
Academic medical centers involved in trials position the company for strong prescriber engagement ahead of a potential 2027 launch.
Beyond BTC, which tumor types offer largest Tovecimig opp
8371's post-checkpoint responses: what's next?
Does PD-1xVEGF also show PD-1 cleavage?
Partial view of Summaries dataset, powered by Quartr API
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Next Compass Therapeutics earnings date
Q4 202526 Feb, 2026
Next Compass Therapeutics earnings date
Q4 202526 Feb, 2026
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Frequently asked questions
Compass Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing antibody-based therapeutics primarily targeting oncology. The company’s research centers on the interaction between angiogenesis, the immune system, and tumor growth. Its pipeline includes novel therapeutic candidates designed to modulate key biological pathways to elicit an effective anti-tumor response. This includes strategies to influence the tumor microvasculature, activate immune cells, and overcome immunosuppressive mechanisms employed by tumors. The company is headquartered in Boston, Massachusetts, and its shares are listed on the NASDAQ.
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