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Compass Therapeutics (CMPX) investor relations material
Compass Therapeutics Morgan Stanley 23rd Annual Global Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Pipeline progress and clinical updates
Lead bispecific antibody Tavecimab achieved primary endpoint in a randomized trial for biliary tract cancer, showing a 17.1% response rate versus 5.3% for control, with statistical significance.
Fewer deaths than projected in the Tavecimab study suggest a potential treatment effect, with updated guidance for secondary endpoint data in Q1 2026.
Investigator-led study at MD Anderson is evaluating Tavecimab in first-line therapy, potentially expanding its use and commercial opportunity.
Phase II basket study for Tavecimab in DLL4-positive cancers is planned for the first half of next year, targeting multiple tumor types.
Fast-track status and potential for a U.S. license application in 2026, with possible approval in early 2027.
Innovation in bispecific antibodies
H371, a PD1-PDL1 bispecific, demonstrated deep responses in refractory non-small cell lung and triple-negative breast cancer patients, with no dose-limiting toxicities in early phase I.
H371’s novel mechanism converts PD1-positive T cells to functional PD1-negative T cells, representing a next-generation checkpoint inhibitor.
Expansion cohorts for H371 in lung and breast cancer will begin in Q4, with full dose escalation data expected at a medical meeting later this year.
10726, a PD1-VEGF8 bispecific, showed superior preclinical efficacy to Ivernizumab and is set for IND filing in Q4, with clinical entry in 2026.
Manufacturing and operational readiness
Developed significant bispecific manufacturing expertise, achieving commercial-ready yields of five grams per liter for all three bispecifics.
BLA-ready manufacturing runs for Tavecimab have been initiated to support potential regulatory filings.
Manufacturing capability is seen as a key differentiator, surpassing yields of some leading monoclonal antibodies.
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