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Connect Biopharma Holdings (CNTB) investor relations material
Connect Biopharma Holdings H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Strategic transformation and leadership
Shifted focus from China to a U.S.-centric model, relocating headquarters to San Diego and overhauling the management team.
Enhanced public company operations, including regular financial filings.
Clinical development and differentiation
Rademikibart, a second-generation IL-4 receptor alpha monoclonal antibody, shows rapid onset of effect in asthma, with over 70% FEV1 benefit achieved within 24 hours.
Differentiated from competitors by targeting acute exacerbations, a market with significant unmet need and no approved biologics for this indication.
Structural differences result in a unique safety profile, notably lacking the hyper-eosinophilia seen with Dupixent.
Commercial and market opportunity
Acute indication serves as a gateway to chronic use, with clinicians expressing strong interest in transitioning patients from acute to chronic therapy if initial results are positive.
Market research indicates a 40-45% preference share for acute use among clinicians.
Chronic asthma and COPD markets offer significant commercial upside, especially with monthly dosing.
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