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Connect Biopharma Holdings (CNTB) investor relations material
Connect Biopharma Holdings H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H.C. Wainwright 27th Annual Global Investment Conference summary8 Sep, 2025
Strategic transformation and leadership
Shifted focus from China to a U.S.-centric model, relocating headquarters to San Diego and overhauling the management team.
Enhanced public company operations, including regular financial filings.
Clinical development and differentiation
Rademikibart, a second-generation IL-4 receptor alpha monoclonal antibody, shows rapid onset of effect in asthma, with over 70% FEV1 benefit achieved within 24 hours.
Differentiated from competitors by targeting acute exacerbations, a market with significant unmet need and no approved biologics for this indication.
Structural differences result in a unique safety profile, notably lacking the hyper-eosinophilia seen with Dupixent.
Commercial and market opportunity
Acute indication serves as a gateway to chronic use, with clinicians expressing strong interest in transitioning patients from acute to chronic therapy if initial results are positive.
Market research indicates a 40-45% preference share for acute use among clinicians.
Chronic asthma and COPD markets offer significant commercial upside, especially with monthly dosing.
Rademikibart's unique acute exacerbation market?
How acute use drives chronic rademikibart adoption?
Phase 3 design for acute exacerbation indication?
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Next Connect Biopharma Holdings earnings date
Q3 202513 Nov, 2025
Next Connect Biopharma Holdings earnings date
Q3 202513 Nov, 2025
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Frequently asked questions
Connect Biopharma Holdings Ltd is a global, clinical-stage biopharmaceutical company focused on developing innovative therapies for chronic inflammatory diseases by leveraging its expertise in T cell biology. The company is advancing a pipeline of novel small molecules and biologics, targeting various conditions such as atopic dermatitis, ulcerative colitis, and chronic pruritus. These therapies aim to address significant unmet medical needs by modulating immune system responses. Connect Biopharma's approach combines a deep understanding of T cell-driven research with proprietary Immune Modulation Technology Platform, aiming to significantly reduce the discovery time and cost for new, effective treatments. The company is headquartered in San Diego, California, and its shares are listed on the NASDAQ.
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