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Connect Biopharma (CNTB) investor relations material
Connect Biopharma Oppenheimer 36th Annual Healthcare Life Sciences Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Strategic focus and clinical development
Lead asset Rademikibart targets IL-4Rα and is positioned as a next-generation antibody for asthma and COPD, with completed studies in atopic dermatitis and chronic asthma.
Licensed to a partner in China, where Phase III atopic dermatitis is complete and a chronic asthma study is ongoing.
Two ongoing studies target acute exacerbations of asthma and COPD, aiming to address a large, underserved global market.
Rademikibart’s unique binding profile offers rapid onset and improved efficacy compared to existing biologics, with significant FEV1 improvements observed within 24 hours.
IV administration is being explored to further accelerate onset, with initial safety and PK data expected soon.
Market opportunity and differentiation
Acute exacerbations represent a major unmet need, with millions of ER visits annually and no approved biologics for acute treatment.
Rademikibart shows a differentiated mechanism, reducing eosinophil levels and enhancing beta-agonist response, unlike dupilumab.
Market research indicates 40-45% preference share for acute use among patients not on biologics, with 75% of clinicians likely to continue chronic use after acute administration.
Acute indication is expected to drive chronic market adoption, with no direct competition due to label restrictions on other biologics.
Peak sales for acute and chronic indications are forecasted at up to $5 billion globally, excluding additional indications.
Regulatory and commercial outlook
Acute studies are designed for rapid readout, with endpoints focused on FEV1 and treatment failure within two weeks.
Phase III for acute indications could be completed within a year, with two studies anticipated due to the novel nature of the indication.
Chronic indication may require only modest bridging studies, leveraging global and China Phase III data.
Cash runway extends into 2027, with significant milestones and royalties expected from China partnership.
Anticipated catalysts include IV pharmacology data, Phase II acute results midyear, and potential atopic dermatitis approval in China by Q3.
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