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Curis (CRIS) investor relations material
Curis H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H.C. Wainwright 27th Annual Global Investment Conference summary10 Sep, 2025
Strategic focus and leadership
Emiflucertib, a first-in-class IRAK4 inhibitor, is the primary focus, targeting lymphoma, leukemia, and solid tumors with proof-of-concept data in PCNSL and AML showing significant improvement over standard care.
Leadership team has extensive experience in drug development, with recent addition of a CMO to drive expansion into CLL.
Mechanism of action and clinical rationale
Emiflucertib blocks key disease-driving pathways (TLR and BCR in CLL/NHL; TLR and FLT3 in AML), enabling synergistic effects with BTK inhibitors.
Combination therapy with BTK inhibitors shows deeper and more durable responses than monotherapy.
The drug aims to address unmet needs by improving efficacy and safety over current standards, including BTK inhibitors and BCL2/CD20 combinations.
Clinical development and results
Clinical program includes dose escalation and expansion in NHL subtypes, with PCNSL selected for fastest regulatory path due to orphan status and lack of approved drugs.
Combination therapy in BTKi-naive PCNSL patients outperformed historical data, and BTKi-experienced patients showed clear tumor reduction and durable remissions.
Safety profile is favorable, with no dose-limiting myelosuppression or significant drug-drug interactions.
AML registrational study financing plan
CLL/NHL expansion strategy beyond PCNSL
Solid tumor data evaluation and next steps
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Next Curis earnings date
Q3 202513 Nov, 2025
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Curis Inc. is a biotechnology company focused on developing innovative therapies for the treatment of cancer. The company's research and development efforts concentrate on targeting signaling pathways that play a key role in the growth and survival of cancer cells. Curis works on both proprietary drug candidates and in collaboration with strategic partners to advance its oncology-focused pipeline. Its therapeutic approach includes small molecules and immunotherapies aimed at addressing various forms of cancer, with the goal of improving patient outcomes. The company is headquartered in Lexington, Massachusetts, and its shares are listed on the NASDAQ.
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