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CytomX Therapeutics (CTMX) investor relations material
CytomX Therapeutics Morgan Stanley 23rd Annual Global Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Platform and pipeline overview
Focus on oncology biologics using a proprietary Probody Therapeutic Platform, which employs antibody masking to improve the therapeutic window for potent anti-cancer agents.
Two lead clinical programs: CX-2051 (EPCAM-targeted masked ADC) and CX-801 (masked interferon alpha 2B).
Masking technology enables targeting of tumor-specific protease activity, activating drugs locally in cancer tissue and reducing off-target toxicity.
EPCAM is a highly expressed, stable antigen in colorectal cancer (CRC), making it an attractive, broadly applicable target.
No patient selection for EPCAM expression required, supporting an all-comer approach in CRC.
Clinical data and safety profile
Phase 1 CX-2051 study in late-line CRC showed a 28% objective response rate and 94% disease control rate in heavily pretreated patients.
Progression-free survival reached 5.8 months, outperforming current fourth-line standards (PFS 3.5–3.7 months, ORR 1–2%).
Safety profile is favorable: no dose-limiting toxicities, manageable hematologic effects, and GI toxicity consistent with TOPO-1 inhibitors.
Masking strategy appears effective, with no observed pancreatic or liver toxicity, differentiating from prior EPCAM-targeted agents.
One grade 5 adverse event (GI toxicity leading to kidney injury in a patient with a solitary kidney) was deemed an outlier; study continues with enhanced monitoring.
Development plans and future directions
Three expansion cohorts (7.2, 8.6, 10 mg/kg) fully enrolled; 70+ patient data update expected in Q1 2026, with six months' follow-up for most.
Next steps include dose selection based on response, PFS, and adverse event analysis, with a randomized study against standard of care planned for 2026.
Combination studies with bevacizumab and chemotherapy are planned to move CX-2051 into earlier CRC treatment lines.
Broader development aims for pan-tumor applications, leveraging EPCAM’s expression in multiple solid tumors.
CX-801 phase 1 in melanoma progressing, with translational biomarker data expected in Q4 and combination data with Keytruda planned for 2026.
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