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Enanta Pharmaceuticals (ENTA) investor relations material
Enanta Pharmaceuticals Jefferies London Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Jefferies London Healthcare Conference 2025 summary18 Nov, 2025
Company overview and pipeline focus
Focuses on virology and immunology, with a history in hepatitis C and current emphasis on RSV and immunology targets.
Two direct-acting antiviral programs for RSV, targeting N and L proteins, with recent positive high-risk adult study data.
Next-generation RSV molecule EDP-323 has shown strong challenge study results.
Expansion into immunology with KIT and STAT6 programs, aiming for oral therapies with best-in-class potential.
Announced new STAT6 development candidate, EPS-3903, with preclinical activity comparable to Dupixent.
RSV clinical data and future plans
High-risk adult RSV study focused on patients 75+, COPD, or congestive heart failure, excluding mild asthmatics.
Treatment shortened time to complete resolution of symptoms by about a week, with broad improvement across 13 symptoms and quality of life measures.
Statistically significant improvement in patient-reported outcomes and reduced hospitalization rate from 5% to 1%.
Positive safety profile observed in over 700 patients, supporting advancement to phase three.
Phase three will likely use a broader symptom endpoint and target the high-risk HR3 population.
Immunology pipeline and differentiation
KIT inhibitor EDP-978 shows strong selectivity, good ADME properties, and is on track for IND filing in Q1.
STAT6 program aims for a best-in-class oral inhibitor, with EPS-3903 showing robust preclinical efficacy in asthma and atopic dermatitis models.
Small molecule approach chosen for predictability and established PK/PD relationships, differentiating from degrader modalities.
STAT6 inhibition with EPS-3903 matches Dupixent in animal models, with continuous 24-hour target engagement.
Plans to announce a third immunology program soon and explore strategic partnerships for RSV assets.
RSV partnership strategy and timeline
KIT: How to ensure therapeutic window?
STAT6 non-degrader competitive advantage?
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Next Enanta Pharmaceuticals earnings date
Evercore ISI 8th Annual HealthCONx Conference3 Dec, 2025
Next Enanta Pharmaceuticals earnings date
Evercore ISI 8th Annual HealthCONx Conference3 Dec, 2025
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Frequently asked questions
Enanta Pharmaceuticals Inc is a biotechnology company focused on the research and development of small molecule drugs targeting viral infections and liver diseases. It specializes in therapies for hepatitis, respiratory infections, and other viral illnesses. The company is headquartered in Watertown, Massachusetts, and its shares are listed on the NASDAQ.
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