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Entrada Therapeutics
Entrada Therapeutics (TRDA) investor relations material
Entrada Therapeutics Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 earnings summary26 Feb, 2026
Executive summary
Multiple clinical programs advancing in Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1), with key data readouts expected in 2026.
Positive recommendation from Data Monitoring Committee to initiate higher dosing in ELEVATE-44-201 study.
Expansion into ocular and metabolic disease programs, including nomination of ENTR-801 for Usher syndrome type 2A.
Financial highlights
Cash, cash equivalents, and marketable securities totaled $295.7 million as of December 31, 2025, down from $420.0 million at year-end 2024.
Collaboration revenue was $1.3 million for Q4 2025 and $25.4 million for FY 2025, compared to $37.4 million and $210.8 million for the same periods in 2024.
R&D expenses were $34.0 million for Q4 and $142.3 million for FY 2025, up from $33.4 million and $125.3 million in 2024.
Net loss was $39.2 million for Q4 2025 and $143.8 million for FY 2025, compared to net income of $1.1 million and $65.6 million in 2024.
Outlook and guidance
Cash runway expected to fund operations into Q3 2027.
Data from ELEVATE-44-201 Cohort 1 expected in Q2 2026, Cohort 2 by year-end 2026, and Cohort 3 to follow.
ELEVATE-45-201 Cohort 1 data expected mid-2026; regulatory filings for ENTR-601-50 and ENTR-601-51 planned for 2026.
Second ocular disease candidate nomination planned for H2 2026.
Why increase ELEVATE-44-102 starting dose?
Future revenue strategy post VX-670 research?
How does expansion cohort accelerate ENTR-601-44?
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Next Entrada Therapeutics earnings date
TD Cowen 46th Annual Health Care Conference3 Mar, 2026
Entrada Therapeutics
Next Entrada Therapeutics earnings date
TD Cowen 46th Annual Health Care Conference3 Mar, 2026
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Frequently asked questions
Entrada Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing a new class of medicines that target intracellular sites traditionally considered unreachable by conventional therapies. The company's proprietary Endosomal Escape Vehicle technology facilitates the efficient intracellular delivery of diverse therapeutic modalities, including RNA, antibodies, and enzymes. This approach is being applied to develop treatments for a range of diseases, particularly in neuromuscular, ocular, metabolic, and immunological areas. The company is headquartered in Boston, Massachusetts, and its shares are listed on the NASDAQ.
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