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Herantis Pharma (HRNTS) investor relations material

Herantis Pharma Study Result summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Study Result summary8 Oct, 2025

Study background and objectives

  • HER-096 is a subcutaneously administered mimic of CDNF, aiming to be the first disease-modifying and neurorestorative treatment for Parkinson's disease.

  • The phase 1b trial evaluated HER-096 in Parkinson's disease patients, focusing on safety, tolerability, and pharmacokinetics, following promising preclinical and phase I-A data.

  • The study included elderly healthy volunteers (part one) and early-stage Parkinson's patients (part two).

  • Inclusion criteria ensured early idiopathic Parkinson's with confirmed dopaminergic deficit and stable medication.

  • The study was conducted at two sites in Finland, funded by The Michael J. Fox Foundation and Parkinson's UK, and completed within timeline and budget.

Study design and patient characteristics

  • Part one: single 300 mg dose in elderly healthy volunteers to assess safety and PK.

  • Part two: 24 Parkinson's patients randomized to 200 mg or 300 mg HER-096 or placebo, two injections per week for four weeks.

  • Cohorts balanced in age, sex, BMI, disease stage, and medication use.

  • Disease duration and symptom severity were similar across groups.

  • All patients used 1–3 symptomatic medications; beta blockers were used for tremor control in some cases.

Safety and tolerability results

  • No serious adverse events related to HER-096; one unrelated SAE occurred in placebo.

  • Most adverse events were mild, transient injection site reactions; systemic AEs were rare.

  • No clinically significant lab, MRI, or hematology abnormalities observed.

  • No evidence of antidrug antibody formation in HER-096 recipients.

  • All participants completed the study without disruptions.

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Frequently asked questions

Herantis Pharma Oyj is a Finnish biotechnology company focused on developing disease-modifying therapies for neurodegenerative diseases, particularly Parkinson's disease. The company's lead program centers around HER-096, a small synthetic chemical designed to mimic the activity of cerebral dopamine neurotrophic factor (CDNF). This treatment aims to address the progression of Parkinson's by protecting neurons and enhancing their function. The company is headquartered in Espoo, Finland, and its shares are listed on the Helsinki Stock Exchange.

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