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Immuneering (IMRX) investor relations material
Immuneering Piper Sandler 37th Annual Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Piper Sandler 37th Annual Healthcare Conference summary4 Dec, 2025
Key clinical results and data
Extraordinary overall survival in Phase 1a: 94% at 6 months, 86% at 9 months for first-line pancreatic cancer patients, significantly outperforming standard of care benchmarks by 27–39 points.
Progression-free survival reached 70% at 6 months and 53% at 9 months; overall response rate was 39% (all confirmed), and disease control rate was 81%, both notably higher than historical controls.
Tumor shrinkage observed as slow and steady, supporting the drug's design for durability and reduced resistance, with most patients experiencing ongoing lesion reduction.
Only anemia and neutropenia (common with chemotherapy) were Grade 3+ adverse events in >10% of patients, indicating favorable tolerability.
Patient population was older (median age 69), yet showed robust survival, adding confidence to results.
Pipeline and development plans
Phase 3 global randomized trial in first-line pancreatic cancer is set to begin dosing mid-2026, with overall survival as the primary endpoint.
Additional Phase 2 combination studies are planned for next year, expanding the clinical pipeline.
Preclinical pipeline of deep cyclic inhibitors is advancing, aiming to further improve durability and tolerability in cancer treatment.
Case studies and clinical anecdotes
Complete response observed in a 71-year-old female on FOLFIRINOX combination, with a liver lesion fully resolved.
Another patient achieved sufficient benefit to undergo curative surgery (Whipple procedure) despite metastatic disease.
Monotherapy case showed over 30% tumor reduction and complete resolution of a bone lesion over 18 months.
Impact of older patient population on OS data?
How does slow tumor shrinkage benefit patients?
Rationale for Phase 3 combination choice?
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Next Immuneering earnings date
Q4 20252 Mar, 2026
Next Immuneering earnings date
Q4 20252 Mar, 2026
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Frequently asked questions
Immuneering Corporation is a clinical-stage oncology company focused on developing novel therapeutics for cancer patients. The company leverages bioinformatics and computational biology to design drugs that cyclically disrupt core oncogenic signaling pathways, such as the MAPK pathway, with the aim of reducing tumor growth while minimizing toxicity. Immuneering’s pipeline includes its lead product candidate, IMM-1-104, a dual-MEK inhibitor in clinical trials targeting cancers caused by mutations in RAS and/or RAF. Another notable candidate is IMM-6-415, also targeting solid tumors. The company emphasizes a disease-agnostic approach, aiming to address cancers with high unmet medical needs through insights derived from its translational bioinformatics platform. The company is headquartered in Cambridge, Massachusetts, and its shares are listed on the NASDAQ.
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