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Jade Biosciences (JBIO) investor relations material
Jade Biosciences Jefferies London Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Jefferies London Healthcare Conference 2025 summary17 Nov, 2025
Company overview and pipeline progress
Founded in June 2024, the team has significant experience in the IgAN space and recruited key talent from Chinook Therapeutics.
Pipeline includes three assets from Paragon, focusing on autoimmune diseases with half-life extension technology.
Lead program, anti-APRIL (JADE101), targets IgA nephropathy, with Phase 1 healthy volunteer study initiated in August 2024 and key readout expected in H1 2025.
Second program, JADE201, is a eufucosylated antibody targeting BAFF-R, aiming for clinic entry in H1 2026.
Third, undisclosed program planned for clinical entry in H1 2027; company is funded to support trials through H1 2028.
Clinical and scientific insights
Anti-APRIL therapy is seen as foundational for IgAN due to its disease-modifying potential and large unmet need, with a $10B+ US market opportunity.
Recent ASN data highlighted strong efficacy of selective anti-APRILs, with sibeprenlimab showing up to 54% proteinuria reduction at 12 months.
Subgroup analysis revealed regional differences in response, possibly linked to dosing strategies and patient characteristics.
Convenience, especially dosing interval, is a key differentiator for long-term therapies in younger IgAN patients.
Duration of APRIL suppression, not just magnitude, is critical for optimal clinical response and remission.
Mechanistic and competitive landscape
Clinical data suggest APRIL inhibition alone provides full efficacy in IgAN, with no added benefit from BAFF inhibition.
BAFF inhibition may introduce unnecessary immunosuppression without improving outcomes in IgAN.
APRIL inhibition may have broader potential in other autoimmune diseases, with ongoing evaluation in indications like Sjögren’s and multifocal motor neuropathy.
The company is open to expanding indications based on emerging data and capital availability.
Safety profile of high-dose anti-APRIL is favorable, with no increased infection risk observed.
JADE101's strategy for optimal APRIL suppression
Impact of FDA's iGAN trial design changes?
JADE201's strategic focus after ianalumab data
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Next Jade Biosciences earnings date
Q4 202525 Mar, 2026
Next Jade Biosciences earnings date
Q4 202525 Mar, 2026
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