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Jaguar Health (JAGX) investor relations material

Jaguar Health Lytham Partners Fall 2025 Investor Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Lytham Partners Fall 2025 Investor Conference summary30 Sep, 2025

Key catalysts and inflection points

  • Recent and upcoming catalysts include FDA meetings, orphan drug applications, and new clinical data releases for crofelemer in cancer and rare diseases.

  • Crofelemer is FDA-approved for HIV-related chronic diarrhea and conditionally approved for chemotherapy-induced diarrhea in dogs.

  • Statistically significant results were achieved in breast cancer patients, leading to an orphan drug application for metastatic breast cancer.

  • Four phase 2 studies are ongoing in intestinal failure, with groundbreaking reductions in parenteral support for MVID and short bowel syndrome.

  • Expanded access programs and supplemental NDA filings are planned to expedite patient access.

Product pipeline and market opportunities

  • Crofelemer is positioned as a pipeline within a product, targeting multiple indications in both human and animal health.

  • The cancer therapy-related diarrhea market is analogous to the $4B chemotherapy-induced nausea market, with long-term therapy needs.

  • Short bowel syndrome represents a $4.5B market opportunity, with orphan designations in the US and Europe.

  • The veterinary market provides valuable commercialization insights and potential cross-market promotional support.

  • Business development efforts focus on non-dilutive partnerships, leveraging de-risked programs for larger deals.

Clinical and regulatory progress

  • Phase 3 trial in cancer therapy-related diarrhea completed; focus shifted to metastatic breast cancer for expedited approval.

  • Orphan drug application filed for metastatic breast cancer, with a treatment trial including all metastatic patients expected to complete in 2026.

  • Investigator-initiated trials in MVID and short bowel syndrome show unprecedented reductions in parenteral nutrition needs.

  • Upcoming FDA meetings aim to expedite approval for ultra-rare diseases with small patient populations.

  • Continued data presentations at major medical conferences are planned.

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Frequently asked questions

Jaguar Health Inc. is a commercial-stage pharmaceutical company focused on developing plant-based gastrointestinal products. The company targets unmet medical needs in human and animal health through proprietary formulations derived from botanical sources. Its development activities support prescription and non-prescription markets. The company is headquartered in San Francisco, California, and its shares are listed on the NASDAQ.

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