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Running on Clouds: The Story of On
The story of how a Swiss runner's pursuit of a new running sensation became On, aiming to be the most premium global sportswear brand worldwide.
MapLight Therapeutics
MapLight Therapeutics (MPLT) investor relations material
MapLight Therapeutics Corporate Presentation summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Corporate Presentation summary9 Jan, 2026
Strategic vision and platform
Focused on improving outcomes for patients with CNS disorders using a circuit-driven discovery engine and diversified pipeline.
Discovery platform identifies and validates novel drug targets causally linked to disease symptoms.
Led by experts in neuropsychiatry and CNS drug development.
Strong financial position with approximately $450M in cash and runway through 2027.
Pipeline and clinical programs
Advancing a broad pipeline including ML-007C-MA for schizophrenia and Alzheimer's disease psychosis (ADP), ML-004 for autism spectrum disorder (ASD), and other candidates for Parkinson's and hyperactivity/impulsivity.
Phase 2 topline results for ML-007C-MA in schizophrenia and ML-004 in ASD expected in Q3 2026; ADP results expected in 2H 2027.
Ongoing studies leverage a circuit-based discovery platform for pipeline expansion.
ML-007C-MA: Lead asset profile
Novel M₁/M4 muscarinic agonist co-formulated with a peripheral antagonist, designed for robust activation and improved safety/tolerability.
Demonstrated strong in vitro and in vivo activity, with potential for comprehensive symptom improvement across positive, negative, and cognitive domains.
Phase 1 studies showed mostly mild and transient adverse events, low rates of vomiting and anticholinergic effects, and no severe or serious events.
Dosing is convenient (QD/BID), with minimal titration and no fasting requirements.
Explain ML-007C-MA's PK differentiation vs KarXT
How does ML-004 address core ASD symptoms?
Assess placebo response mitigation for ZEPHYR trial
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Next MapLight Therapeutics earnings date
Q4 202513 Apr, 2026
MapLight Therapeutics
Next MapLight Therapeutics earnings date
Q4 202513 Apr, 2026
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