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Maze Therapeutics (MAZE) investor relations material
Maze Therapeutics Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Evercore ISI 8th Annual HealthCONx Conference summary3 Dec, 2025
Key accomplishments and milestones
Went public early in the year, enabling company transformation and growth.
Initiated the MZE829 study for APOL1 kidney disease, with data expected by end of Q1 2026.
Released additional data on MZE782 in September, which was well received.
Completed a PIPE financing to support ongoing and future studies.
Advanced multiple product candidates and secured capital for upcoming data catalysts.
APOL1 kidney disease program insights
APOL1-mediated kidney disease affects about one million in the U.S., with 250,000 likely to benefit from new therapies.
Disease progresses faster and affects younger patients, with no approved therapies currently available.
MZE829 targets a broad spectrum of AMKD patients, both with and without diabetes.
The market size is comparable to or larger than the IgAN market, representing a significant unmet need.
MZE829 offers a dual mechanism, blocking and disrupting APOL1 pore assembly, showing greater potency than competitors.
Clinical trial design and expectations
Horizon study requires genotyped patients (G1 or G2), treated for three months and followed for one month.
Aims to demonstrate at least a 30% reduction in proteinuria using UACR as a sensitive endpoint.
Includes both diabetic and non-diabetic patients, with an eight-week lead-in on standard of care.
Initial data will focus on broad AMKD, excluding highly proteinuric FSGS patients.
Achieving a 30% reduction in proteinuria is considered a clinical win and would trigger planning for a phase 2b/3 study.
MZE829 dual mechanism: competitive implications
APOL1 market: Maze's competitive strategy
MZE782: CKD proof of mechanism significance
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Next Maze Therapeutics earnings date
Q4 202531 Mar, 2026
Next Maze Therapeutics earnings date
Q4 202531 Mar, 2026
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