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Maze Therapeutics (MAZE) investor relations material
Maze Therapeutics 44th Annual J.P. Morgan Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Strategic vision and pipeline progress
Focus on precision medicines for kidney and metabolic diseases using human genetics, with a strong pipeline and near-term catalysts expected in 2026 and beyond.
Multiple clinical programs underway, including MZE829 for APOL1 kidney disease and MZE782 for PKU and chronic kidney disease.
Operating capital secured into 2028, supporting all planned milestones and studies.
Differentiated platform and team enable execution of milestones and expansion into additional programs.
Commitment to updating stakeholders on progress, with key data readouts expected soon.
MZE829 for APOL1 kidney disease
Addresses a significant unmet need with no approved therapies for APOL1-mediated kidney disease, affecting at least 250,000 individuals in the U.S.
Phase II HORIZON study is ongoing, targeting a clinically meaningful ≥30% reduction in UACR; top-line proof-of-concept data expected by end of Q1 2026.
Study includes both diabetic and non-diabetic patients, with a third cohort for highly proteinuric FSGS patients.
Positive phase I data supported advancement, showing a favorable safety profile and dose selection for broad AMKD.
If successful, planning for phase IIB/III and potential registration strategies will begin.
MZE782 for PKU and chronic kidney disease
MZE782 aims to address PKU by enabling a more normal diet and reducing phenylalanine accumulation, with phase II study initiation planned for mid-2026.
Demonstrated >40-fold increase in urinary phenylalanine excretion in phase I, exceeding benchmarks and generating strong enthusiasm.
Also advancing in chronic kidney disease, with phase II start targeted for the second half of 2026.
Preclinical and phase I data show potential to complement or replace SGLT2 inhibitors, with additive effects and a similar eGFR dip indicating long-term renal protection.
Strategic sequencing prioritizes PKU for a clear registrational path, with pricing and product configuration considerations for broader indications.
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