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Edge12 Dec 2025
Running on Clouds: The Story of On
The story of how a Swiss runner's pursuit of a new running sensation became On, aiming to be the most premium global sportswear brand worldwide.
Mereo Biopharma Group
Mereo Biopharma Group (MREO) investor relations material
Mereo Biopharma Group 44th Annual J.P. Morgan Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.44th Annual J.P. Morgan Healthcare Conference summary14 Jan, 2026
Key program updates and financial overview
Three main clinical programs: setrusumab (OI, phase III), alvelestat (AATD, phase III-ready), and vantictumab (osteopetrosis, phase I-II/IND planned for H2 2024/2026).
$41 million in cash as of December 31, 2025, with runway guidance extending to mid-2027.
All programs target large patient populations with high unmet need and lack of approved therapies.
Management team has a strong track record in corporate development.
Strategic vision and rare disease focus
Aims to transform lives of patients with rare diseases lacking effective therapies.
Addresses high unmet needs and significant market opportunities in rare bone and lung disorders.
Setrusumab phase III results and analysis
ORBIT and COSMIC studies did not meet primary endpoints but showed robust, statistically significant BMD improvements and pain reduction.
COSMIC showed a 21% reduction in annualized fracture rate vs. bisphosphonates and a 59% reduction in vertebral fractures.
Statistically significant improvements in pain and daily activities reported in pediatric and adolescent patients.
No new safety concerns identified; adverse events consistent with expected profile.
Open-label extension ongoing, with over 200 patients enrolled for long-term follow-up.
Setrusumab: Path forward post-Phase 3 data?
Alvelestat: Partnering status and Phase 3 timeline?
Vantictumab: How prior data de-risks ADO2 IND?
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Next Mereo Biopharma Group earnings date
Q4 202526 Mar, 2026
Mereo Biopharma Group
Next Mereo Biopharma Group earnings date
Q4 202526 Mar, 2026
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Frequently asked questions
Mereo Biopharma Group plc is a biopharmaceutical company that focuses on the development and commercialization of therapies for rare diseases and oncology. The company has a diverse portfolio of product candidates in various stages of clinical development, including treatments for conditions such as osteogenesis imperfecta, Alpha-1 anti-trypsin deficiency, and different types of cancer. Among its leading candidates are etigilimab, an antibody designed for tumor treatment, and alvelestat, intended for Alpha-1 anti-trypsin deficiency. Founded in 2015, Mereo Biopharma Group plc is headquartered in London, United Kingdom, and its shares are listed on the NASDAQ.
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