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Monte Rosa Therapeutic (GLUE) investor relations material
Monte Rosa Therapeutic TD Cowen Immunology and Inflammation Summit summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.TD Cowen Immunology and Inflammation Summit summary13 Nov, 2025
Company overview and strategy
Focuses on molecular glue degraders to target previously undruggable proteins in inflammation, immunity, and oncology.
Operates from Boston and Basel, with three clinical programs: Vav1 degrader (MRT-6160), NEK7 degrader (MRT-8102), and GSPT-1 degrader (MRT-2359).
Vav1 degrader licensed to Novartis and advancing to phase two; NEK7 and GSPT-1 programs are in clinical trials.
NEK7 degrader (MRT-8102) program
NEK7 is essential for NLRP3 inflammasome assembly; degrading NEK7 prevents inflammasome formation, differentiating it from NLRP3 inhibitors.
Preclinical and GLP toxicology studies in animals showed no significant safety concerns at high doses.
Proteomic data indicate high selectivity for NEK7, with no off-target degradation among NEK family proteins.
Degradation leads to sustained inhibition, as NEK7 levels take days to recover post-treatment.
Phase one includes healthy volunteers and patients with cardiovascular risk; data readout expected in the first half of next year.
Biomarkers and clinical endpoints
CRP is a key pharmacodynamic marker, with established benchmarks from prior IL-1/NLRP3 studies.
Cytokines like IL-1β, IL-18, and IL-6 are also tracked, though require ex vivo stimulation in healthy subjects.
Phase one design incorporates standard single and multiple ascending dose parts, plus a patient cohort with elevated CRP.
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Next Monte Rosa Therapeutic earnings date
Jefferies London Healthcare Conference 202518 Nov, 2025
Next Monte Rosa Therapeutic earnings date
Jefferies London Healthcare Conference 202518 Nov, 2025
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Frequently asked questions
Monte Rosa Therapeutics Inc. is a clinical-stage biotechnology company focused on developing molecular glue degraders (MGDs). These small molecules are designed to selectively degrade disease-causing proteins by harnessing the body’s natural protein degradation processes. The company targets a range of therapeutic areas, including oncology, autoimmune, and inflammatory diseases. Monte Rosa utilizes its proprietary QuEEN platform, which integrates proteomics, structural biology, AI, and machine learning, to rapidly identify and develop highly selective protein degraders. The company operates out of Boston, Massachusetts, with additional research facilities in Basel, Switzerland. Its shares trade on the NASDAQ.
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