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Neumora Therapeutics (NMRA) investor relations material

Neumora Therapeutics H.C. Wainwright 27th Annual Global Investment Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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H.C. Wainwright 27th Annual Global Investment Conference summary9 Sep, 2025

Obesity and NLRP3 Inhibitor Program

  • NLRP3 inhibitor targets CNS-mediated pathways to suppress appetite, offering a novel mechanism distinct from incretins and amylins.

  • Oral, once-daily small molecule formulation aims for high brain penetration, improved tolerability, and affordability compared to injectables.

  • Upcoming DIO mouse model data expected later this year will inform clinical development, with monotherapy, combination, and maintenance paradigms under evaluation.

  • Plans to enter clinical trials in 2026, starting with monotherapy and expanding to combination and maintenance studies if preclinical data supports.

  • Potential benefits include lean muscle mass sparing, reduced GI side effects, and broader metabolic and cardiovascular utility.

M4 PAM Franchise and Clinical Strategy

  • Two M4 positive allosteric modulators (PAMs) are advancing, with one in phase 1 and another entering the clinic by year-end, both optimized for brain penetration and safety.

  • The franchise approach allows for targeting multiple neuropsychiatric and neurodegenerative indications, including schizophrenia and dementia-related psychosis.

  • Phase 1 studies include stable schizophrenia patients to assess dose tolerance, PK, and side effect profiles, with prioritization of the lead asset for proof-of-concept studies.

  • Early data will guide whether both assets pursue schizophrenia or diverge into other indications.

Updates on Coastal and 511 Programs

  • Coastal studies were paused and refined to improve patient selection and site quality, with new screening processes to ensure higher data integrity.

  • Enrollment guidance for COSTAL 2 and 3 remains for 2026, with operational changes expected to address prior placebo response issues.

  • The 511 program targets Alzheimer's agitation, with phase 1b data expected by year-end; aims for better tolerability than current therapies and focuses on outpatient populations.

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Frequently asked questions

Neumora Therapeutics Inc., known as NMRA, is a clinical-stage biopharmaceutical company focused on the development of therapeutic treatments for brain diseases, neuropsychiatric disorders, and neurodegenerative diseases. Founded in 2019 and formerly known as RBNC Therapeutics, Inc., Neumora aims to redefine neuroscience drug development by integrating data science with neuroscience to pioneer precision medicines for complex brain diseases. The company's pipeline includes various programs at different stages of clinical trials targeting diseases such as major depressive disorder, agitation associated with dementia due to Alzheimer's disease, schizophrenia, amyotrophic lateral sclerosis, and Parkinson's disease, among others. The company is headquartered in Watertown, Massachusetts, and its shares are listed on the Nasdaq.

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