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Investor Relations14 Oct 2025
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PepGen (PEPG) investor relations material
PepGen Q2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q2 2025 earnings summary7 Aug, 2025
Executive summary
Discontinued PGN-EDO51 for Duchenne muscular dystrophy after failing to achieve target dystrophin levels; all DMD-related R&D activities wound down.
Focus shifted to PGN-EDODM1 for myotonic dystrophy type 1, with ongoing Phase 1 and Phase 2 trials and positive initial safety and splicing correction data.
Completed dosing in the 15 mg/kg cohort of the FREEDOM Phase 1 trial for DM1; topline data expected early Q4 2025.
Transitioning clinical sites to the FREEDOM2 Phase 2 multiple ascending dose trial, with initial results from the 5 mg/kg cohort anticipated in Q1 2026.
Appointed a new Chief Technology Officer in May 2025, bringing extensive experience in product and process development.
Financial highlights
Cash, cash equivalents, and marketable securities totaled $74.7 million as of June 30, 2025, expected to fund operations into Q2 2026.
Net loss for the six months ended June 30, 2025, was $53.3 million; Q2 2025 net loss was $23.1 million ($0.70 per share), down from $28.3 million in Q2 2024.
Research and development expenses were $43.8 million for the first half of 2025, with Q2 2025 R&D at $18.4 million, down from $25.1 million year-over-year.
General and administrative expenses were $11.5 million for the first half of 2025, with Q2 2025 at $5.5 million, nearly flat year-over-year.
No revenue generated from product sales to date; all funding from equity offerings and financings.
Outlook and guidance
Existing cash and equivalents expected to fund operations into Q2 2026; additional capital will be required to continue operations beyond that point.
Topline data from the 15 mg/kg cohort of the FREEDOM trial expected in early Q4 2025; initial results from the 5 mg/kg cohort of the FREEDOM2 trial anticipated in Q1 2026.
Focused on advancing PGN-EDODM1 through ongoing and planned clinical trials, with key data readouts expected in late 2025 and early 2026.
Expenses and operating losses expected to continue as clinical and preclinical programs progress.
Explain the rationale to conclude FREEDOM with 15 mg/kg cohort.
Assess the impact of Kasra Kasraian's appointment.
How will PepGen fund operations beyond Q2 2026?
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Next PepGen earnings date
Q3 20256 Nov, 2025
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Frequently asked questions
PepGen Inc. is a biotechnology company focused on developing nucleic acid-based therapies for neuromuscular and rare genetic diseases. The company specializes in peptide-conjugated oligonucleotide therapeutics designed to enhance drug delivery and effectiveness. Its research and development efforts target conditions such as Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1). The company is headquartered in Boston, Massachusetts, and its shares are listed on the NASDAQ.
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