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PMV Pharmaceuticals (PMVP) investor relations material
PMV Pharmaceuticals Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q3 2025 earnings summary12 Nov, 2025
Executive summary
Focused on developing small molecule, tumor-agnostic therapies targeting p53 mutations, with lead candidate rezatapopt in Phase 2 clinical trials for ovarian cancer and other solid tumors.
Updated Phase 2 PYNNACLE study results for rezatapopt showed a 34% overall response rate (ORR) among 103 evaluable patients, with a median response duration of 7.6 months.
Ovarian cancer cohort achieved a 46% ORR and 8.0 months median response duration; NDA submission for platinum-resistant/refractory ovarian cancer planned for Q1 2027.
Reported net losses of $21.1 million for Q3 2025 and $59.7 million for the nine months ended September 30, 2025, reflecting ongoing R&D investment.
No product revenue generated to date; operations funded through equity offerings and available cash.
Financial highlights
Cash, cash equivalents, and marketable securities totaled $129.3 million as of September 30, 2025, down from $183.3 million at year-end 2024 and $148.3 million at June 30, 2025.
Research and development expenses were $18.2 million for Q3 2025 (up $1.3 million year-over-year) and $54.1 million for the nine months, mainly due to increased clinical trial costs.
General and administrative expenses decreased to $4.3 million for Q3 2025 and $12.9 million for the nine months, reflecting lower personnel, stock-based compensation, and facility costs.
Net cash used in operations was $56.4 million for the nine months ended September 30, 2025, versus $34.6 million for the same period in 2024.
Net loss per share was $(0.40) for Q3 2025 and $(1.14) for the nine months ended September 30, 2025.
Outlook and guidance
Cash runway expected to fund operations through the end of Q1 2027, based on current R&D plans.
NDA submission for rezatapopt in platinum-resistant/refractory ovarian cancer planned for Q1 2027.
Anticipates increased operating expenses as clinical development progresses and regulatory submissions approach.
Plans to complete enrollment in the ovarian cohort of the pivotal Phase 2 study by Q1 2026.
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Next PMV Pharmaceuticals earnings date
Q4 20252 Mar, 2026
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Q4 20252 Mar, 2026
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PMV Pharmaceuticals Inc. is a U.S.-based biotechnology company focused on the discovery and development of targeted therapies for cancer. The company specializes in precision oncology, aiming to create treatments that address specific genetic mutations in cancer cells. Its work spans early-stage drug discovery through clinical development. The company is headquartered in Princeton, New Jersey, and its shares are listed on the NASDAQ.
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