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PMV Pharmaceuticals
PMV Pharmaceuticals (PMVP) investor relations material
PMV Pharmaceuticals Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 earnings summary6 Mar, 2026
Executive summary
Achieved positive Phase 2 interim data for rezatapopt in the PYNNACLE trial for TP53 Y220C-mutated cancers.
Enrollment remains on track for the pivotal Phase 2 portion, with NDA submission planned for Q1 2027.
Rezatapopt received Orphan Drug Designation and Fast Track status from the FDA for TP53 Y220C positive ovarian cancer.
Published first-in-human data in NEJM showing selective p53 reactivation and antitumor activity.
Financial highlights
Cash, cash equivalents, and marketable securities totaled $112.9 million as of December 31, 2025, down from $183.3 million at year-end 2024.
Net loss for 2025 was $77.7 million, compared to $58.7 million in 2024.
Net cash used in operations was $73.6 million for 2025, up from $51.3 million in 2024.
R&D expenses rose to $69.9 million in 2025, primarily due to advancing rezatapopt clinical development.
G&A expenses decreased to $16.3 million in 2025, reflecting lower facility and personnel costs after relocation and staff reductions.
Outlook and guidance
Cash runway expected to last through the end of Q2 2027.
NDA submission for rezatapopt in platinum-resistant/refractory ovarian cancer planned for Q1 2027.
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Next PMV Pharmaceuticals earnings date
Q1 20268 May, 2026
PMV Pharmaceuticals
Next PMV Pharmaceuticals earnings date
Q1 20268 May, 2026
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PMV Pharmaceuticals Inc. is a U.S.-based biotechnology company focused on the discovery and development of targeted therapies for cancer. The company specializes in precision oncology, aiming to create treatments that address specific genetic mutations in cancer cells. Its work spans early-stage drug discovery through clinical development. The company is headquartered in Princeton, New Jersey, and its shares are listed on the NASDAQ.
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