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ProMIS Neurosciences (PMN) investor relations material
ProMIS Neurosciences Guggenheim Securities Emerging Outlook: Biotech Summit 2026 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Key milestones and financial position
Completed enrollment of 144 patients in a robust, oversubscribed phase 1b Alzheimer's study in December, with full financing secured through upcoming data readouts.
Raised up to $175 million in an oversubscribed financing round led by top-tier investors, ensuring funding through key clinical milestones.
Interim analysis of trial data is expected mid-year, with final top-line results anticipated by year-end.
The study design features monthly dosing over 12 months, dose escalation, and placebo control for early Alzheimer's patients.
High patient retention and investigator enthusiasm have resulted in over-enrollment and strong trial execution.
Scientific platform and differentiation
Proprietary EpiSelect platform enables design of highly selective antibodies targeting toxic oligomers, believed to drive neurodegeneration.
PMN310 is the only antibody in development shown not to bind plaque or monomers, focusing exclusively on toxic oligomers.
Preclinical studies demonstrate strong efficacy and safety, with no plaque binding and reduced risk of ARIA compared to other therapies.
The platform supports a pipeline targeting ALS, Parkinson's, and Lewy body dementia, with proof of concept in Alzheimer's expected to validate broader applications.
The approach is now gaining industry acceptance, with other companies shifting focus to oligomers, but PMN310 remains uniquely selective.
Clinical trial design and endpoints
The Precise AD trial is a 12-month, placebo-controlled, double-blind, randomized phase 1b study with three ascending doses (5, 10, 20mg/kg).
Enrolled patients have early Alzheimer's (MCI due to AD), with a homogeneous population screened for disease presence.
Endpoints include a comprehensive biomarker panel, safety (especially ARIA), and clinical outcomes using FDA-approved measures (CDR sum of boxes, ADAS-Cog).
The study is powered to detect ARIA, with front-loaded MRIs to capture early events; over 90% of ARIA cases in similar studies occur within six months.
No treatment-related serious adverse events or ARIA have been observed to date, and dropout rates are significantly lower than industry norms.
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