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ProMIS Neurosciences (PMN) investor relations material
ProMIS Neurosciences Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Evercore ISI 8th Annual HealthCONx Conference summary2 Dec, 2025
State of the business and industry
Focused on advancing a phase I-B clinical study for Alzheimer's, with consistent progress and guidance maintained throughout the year.
The Alzheimer's treatment landscape remains open for novel drugs due to limitations and side effects of current market options.
Enrollment for the phase I-B trial is on track to complete by year-end, with interim analysis expected in Q2 and top-line results in Q4 of the following year.
The lead asset, PMN310, is an amyloid beta monoclonal antibody targeting toxic oligomers rather than plaque.
Scientific rationale and differentiation
Industry focus has shifted from targeting amyloid plaque to toxic oligomers, which are now seen as the main drivers of disease progression.
PMN310 is designed to selectively target low molecular weight oligomers, believed to be the most toxic species.
Competing drugs often cross-react with plaque, leading to side effects like ARIA, while PMN310 aims to minimize this risk.
Clinical trial design and safety
The phase I-B PRECISE-AD trial targets 128 patients to ensure at least 100 completers, with three dosing cohorts (5, 10, 20 mg/kg).
Safety profile has been strong, with ARIA rates expected to be similar to placebo and lower than other drugs.
Interim analysis will focus on safety and biomarker endpoints, not direct clinical efficacy.
Biomarkers such as pTau217, pTau243, neurogranin, GFAP, and SNAP-25 will be used to infer potential clinical benefit.
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Next ProMIS Neurosciences earnings date
Q4 202530 Mar, 2026
Next ProMIS Neurosciences earnings date
Q4 202530 Mar, 2026
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Frequently asked questions
ProMIS Neurosciences Inc is a Canada-based biotechnology company focused on the discovery and development of antibody therapeutics for neurodegenerative diseases. The company uses a proprietary computational platform to design monoclonal antibodies that selectively target toxic misfolded proteins implicated in conditions such as Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and Parkinson's disease. ProMIS conducts preclinical and early-stage clinical development in collaboration with academic and industry partners. The company is headquartered in Toronto, Ontario, and its shares are listed on the TSX.
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