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ProMIS Neurosciences (PMN) investor relations material
ProMIS Neurosciences H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H.C. Wainwright 27th Annual Global Investment Conference summary10 Sep, 2025
Company overview and technology
Focuses on protein misfolding as the basis for antibody therapies targeting neurodegenerative diseases.
Utilizes the EpiSelect platform to generate highly selective antibodies.
Lead program, PMN310, is in clinical development for Alzheimer's disease.
Pipeline includes candidates for ALS, Parkinson's, MSA, and a vaccine program.
Emphasizes differentiation in efficacy and safety, especially regarding ARIA side effects.
Clinical development and trial progress
Phase 1b study for PMN310 is enrolling ahead of schedule at 22 US sites, with over 100 patients treated.
The study is placebo-controlled, randomized, and spans 12 months, focusing on biomarkers, safety, and clinical endpoints.
FDA fast track designation and DSMB approval to escalate dosing have been achieved.
Interim analysis is expected in Q2 next year, with final top-line results in Q4.
No cases of ARIA have been observed to date, with a safety profile comparable to placebo.
Scientific rationale and differentiation
PMN310 selectively targets toxic amyloid beta oligomers, avoiding monomers and plaque.
Preclinical and clinical data show no binding to plaque and no evidence of brain hemorrhage in animal studies.
The antibody is designed to maximize efficacy by focusing on the most pathogenic species.
Other marketed drugs bind plaque and monomers, leading to modest efficacy and higher ARIA risk.
The platform's computational approach enables precise epitope targeting.
How does PMN310's ARIA profile aid market uptake?
How does skipping Phase 2 accelerate market entry?
How does selective oligomer targeting improve efficacy?
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Next ProMIS Neurosciences earnings date
Q3 202512 Nov, 2025
Next ProMIS Neurosciences earnings date
Q3 202512 Nov, 2025
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Frequently asked questions
ProMIS Neurosciences Inc is a Canada-based biotechnology company focused on the discovery and development of antibody therapeutics for neurodegenerative diseases. The company uses a proprietary computational platform to design monoclonal antibodies that selectively target toxic misfolded proteins implicated in conditions such as Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and Parkinson's disease. ProMIS conducts preclinical and early-stage clinical development in collaboration with academic and industry partners. The company is headquartered in Toronto, Ontario, and its shares are listed on the TSX.
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