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Prothena Corporation (PRTA) investor relations material
Prothena Corporation Cantor Global Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Recent corporate developments
Multiple pipeline updates and positive news from partners, including Roche and Novo, with both moving key molecules into phase three studies this year.
Restructuring led to a right-sized organization focused on ongoing partner obligations and new partnership opportunities.
Shareholder-friendly financial activities, including plans for distributable reserves and potential share repurchase, are underway.
Operational clarity and focus on near-term value creation, with $105M in clinical milestones achievable next year.
End-of-year cash guidance is $300M, with further 2026 guidance to be provided early next year.
Pipeline and partnership updates
Roche is advancing prasinezumab for Parkinson’s disease into phase three, with additional data expected and a large market opportunity projected.
Novo Nordisk is moving Kuramitug for ATTR cardiomyopathy into phase three, with a significant milestone payment expected upon enrollment.
Four active partnership programs: two entering phase three, one phase two readout in 2027, and one phase one with Bristol Myers Squibb.
Ongoing efforts to partner unpartnered programs and fulfill R&D obligations for current collaborations.
Partnership economics include up to $755M in milestones and royalties with Roche, and $1.23B in milestones and royalties with Novo Nordisk.
Clinical and scientific highlights
PRX012, an anti-amyloid beta antibody for Alzheimer’s, showed strong potency and favorable PK but higher than expected ARIA rates; a transferrin-based approach is being considered to mitigate this.
Prasinezumab targets aggregated alpha synuclein in Parkinson’s, with consistent effects across studies and a unique biological profile.
Kuramitug targets misfolded transthyretin in ATTR amyloidosis, aiming to clear resident amyloid and prevent new aggregation, with encouraging early clinical data.
Phase two and three studies are designed to address both symptomatic and disease-modifying aspects in neurodegenerative diseases.
Future milestones include clinical data readouts, regulatory decisions, and potential commercial launches.
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