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Prothena
Prothena (PRTA) investor relations material
Prothena Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 earnings summary19 Feb, 2026
Executive summary
Advanced partnered programs prasinezumab (Parkinson's), coramitug (ATTR-CM), BMS-986446 (Alzheimer's), and PRX019 (neurodegeneration) into later-stage trials, achieving significant clinical milestones in 2025.
Introduced CYTOPE technology for precise intracellular targeting, with promising preclinical ALS data and ongoing research collaborations.
Strategic priorities for 2026 include capturing up to $105M in clinical milestones, implementing a share redemption program, and advancing preclinical portfolio.
Ended 2025 with $308.4M in cash, supporting ongoing and future development activities.
Shareholder and court approval obtained for a share redemption program in 2026.
Financial highlights
Net cash used in operating and investing activities for 2025 was $163.7M, favorable to guidance.
Net loss for 2025 was $244.1M, in line with guidance, including $37.6M in non-cash share-based compensation.
Year-end 2025 cash and restricted cash totaled $308.4M, above guidance.
No debt and 53.8M shares outstanding as of year-end 2025.
Total revenue for 2025 was $9.7M, down from $135.2M in 2024, primarily due to lower collaboration revenue.
Outlook and guidance
2026 net cash used in operating and investing activities expected to be $50M–$55M.
Year-end 2026 cash projected at $255M, not including up to $105M in potential milestone payments.
Estimated 2026 net loss of $67M–$72M, including $24M in non-cash share-based compensation.
What factors drive 2026 share redemption decision?
Detail PRX012-TfR partnership exploration
How will future royalties impact revenue profile?
CYTOPE: What's the BD strategy beyond research?
PRX012-TfR: When will ARIA-E data be available?
Share redemption program: What's the scale?
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Next Prothena earnings date
The Citizens Life Sciences Conference 202611 Mar, 2026
Prothena
Next Prothena earnings date
The Citizens Life Sciences Conference 202611 Mar, 2026
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Frequently asked questions
Prothena Corporation plc is a late-stage clinical biotechnology company focused on the discovery and development of novel therapies for diseases caused by protein dysregulation. The company's portfolio includes a range of investigational humanized antibodies and other therapeutic candidates targeting conditions such as AL amyloidosis, Parkinson's disease, ATTR amyloidosis, and Alzheimer's disease. Prothena's approach leverages insights into the biology of misfolded proteins to develop therapies aimed at changing the course of neurodegenerative and rare peripheral amyloid diseases. The company is headquartered in Dublin, Ireland, and its shares are listed on the Nasdaq.
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