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Q32 Bio (QTTB) investor relations material
Q32 Bio Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q3 2025 earnings summary13 Nov, 2025
Executive summary
Completed enrollment in Part B of the SIGNAL-AA Phase 2a trial for bempikibart in alopecia areata, increasing trial size to 33 patients due to strong demand; topline data expected mid-2026.
Announced FDA Fast Track designation for bempikibart in April 2025.
Ongoing dosing in Part A open-label extension, with emerging data suggesting remittive and durable responses.
Discontinued Phase 2 trial of ADX-097 and implemented a strategic restructuring to focus on bempikibart, including a reduction in force.
Regained full development and commercial rights to bempikibart after terminating the Horizon agreement, resolving a $55M refund liability via equity issuance.
Financial highlights
Cash and cash equivalents were $49.0M as of September 30, 2025, expected to fund operations into 2027.
Net loss for Q3 2025 was $7.4M ($0.60 per share), compared to $17.6M ($1.46 per share) for Q3 2024.
Research and development expenses were $3.6M for Q3 2025, down from $14.3M in Q3 2024, mainly due to lower bempikibart and discontinued ADX-097 program costs.
General and administrative expenses were $4.0M for Q3 2025, down from $4.5M in Q3 2024.
No product revenue generated; company remains pre-commercial.
Outlook and guidance
Cash runway projected into 2027, but additional capital will be needed to advance programs through regulatory approval and commercialization.
Topline data from SIGNAL-AA Part B expected mid-2026; pivotal trial advancement contingent on results.
Ongoing evaluation of strategic options for complement inhibitor platform assets.
Quantify earlier responsiveness from loading regimen
Future R&D spend for bempikibart development
Bempikibart's durability vs. current AA treatments
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Frequently asked questions
Q32 Bio Inc. is a clinical-stage biotechnology company focused on developing biologic therapeutics designed to restore immune balance in patients with autoimmune and inflammatory diseases. The company's product pipeline includes innovative treatments targeting both the innate and adaptive immune systems. The company is based in Waltham, Massachusetts, and its shares are listed on the NASDAQ.
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