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Rapport Therapeutics (RAPP) investor relations material
Rapport Therapeutics Jefferies London Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Jefferies London Healthcare Conference 2025 summary17 Nov, 2025
Strategic focus and technology platform
Focused on precision neuroscience using receptor-associated proteins, with lead program RAP-219 targeting TARPγ8 AMPA modulation in specific brain regions.
RAP-219 aims to provide precise modulation of AMPA receptors, translating to a novel anti-seizure medication profile.
Clinical milestones and data highlights
Phase II proof-of-concept results for RAP-219 showed over 70% seizure reduction and 24% of patients achieving seizure freedom over eight weeks.
RAP-219 demonstrated a strong safety and tolerability profile, with only mild or moderate adverse events and no severe or serious events.
Nearly 70% of patients in the study were on three or four background anti-seizure medications, highlighting efficacy in a treatment-resistant population.
Full trial results and open-label extension data will be shared in 2024 and 2026, with additional insights expected at the AES conference.
Market opportunity and product profile
U.S. market for focal onset seizures is estimated at $10–15 billion, with 1.8 million patients and 30–40% treatment-resistant.
RAP-219 offers a novel mechanism, strong tolerability, once-daily dosing, long half-life, and minimal drug-drug interactions, supporting broad use from third-line to first-line therapy.
Development of a long-acting injectable formulation is underway, aiming to address unmet needs and expand market potential.
RAP-219 market strategy given profile
LAI program's regulatory path
Bipolar program's value proposition
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Next Rapport Therapeutics earnings date
Q4 202511 Mar, 2026
Next Rapport Therapeutics earnings date
Q4 202511 Mar, 2026
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Frequently asked questions
Rapport Therapeutics Inc. is a clinical-stage biopharmaceutical company dedicated to the discovery and development of small-molecule medicines targeting central nervous system disorders. The company's research focuses on understanding neuronal receptor biology to design precision treatments that address the complexities of neurological conditions. By mapping and targeting specific neuronal receptor complexes, Rapport aims to regulate receptor function and expression effectively. The company is headquartered in Boston, Massachusetts, and its shares are listed on NASDAQ.
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