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Revolution Medicines (RVMD) investor relations material
Revolution Medicines Study Result summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Study Result summary10 Sep, 2025
Disease background and unmet need
Pancreatic ductal adenocarcinoma (PDAC) is highly lethal, with a five-year survival rate of 3% and over 90% of cases harboring RAS driver mutations, making RAS a key therapeutic target.
Most patients are diagnosed at a metastatic stage, where cytotoxic chemotherapy is the global standard but outcomes remain poor.
There is a significant need for improved efficacy and tolerability in both first- and second-line PDAC treatments.
Mechanism and preclinical data
Daraxonrasib (diraxonrasib) is a multi-selective RAS(ON) inhibitor targeting nearly all oncogenic RAS variants, including wildtype.
Preclinical models showed deep, durable monotherapy and combination activity, with improved response when combined with gemcitabine/nab-paclitaxel (GnP/GMP).
Clinical results: second-line PDAC
In second-line PDAC, daraxonrasib monotherapy achieved a 35% ORR in RAS G12X and 29% in all RAS mutant patients, with DCRs of 92–95%, median PFS of 8.1–8.5 months, and median OS of 13.1–15.6 months.
Safety profile was manageable, with 96% experiencing any-grade TRAEs and 34% grade ≥3; dose modifications were required in 48% of patients.
Rationale for sequential combo-to-mono strategy?
How will daraxonrasib shift PDAC treatment paradigms?
How to ensure RASolute 303 patient fitness for all arms?
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Next Revolution Medicines earnings date
Q3 20255 Nov, 2025
Next Revolution Medicines earnings date
Q3 20255 Nov, 2025
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Frequently asked questions
Revolution Medicines Inc. is a biopharmaceutical company focused on discovering and developing targeted therapies for cancer. The company specializes in small-molecule inhibitors that address oncogenic mutations in the RAS signaling pathway, a key driver of many cancers. Revolution Medicines utilizes advanced drug discovery technologies to develop treatments for patients with genetically defined cancers. Revolution Medicines Inc. is headquartered in Redwood City, California, and its shares are listed on the NASDAQ.
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