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Rhythm Pharmaceuticals
Rhythm Pharmaceuticals (RYTM) investor relations material
Rhythm Pharmaceuticals Corporate Presentation summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Corporate Presentation summary9 Jan, 2026
Strategic positioning and financial overview
IMCIVREE (setmelanotide) is available in over 25 countries, with a strong global commercial infrastructure and expanding indications for rare genetic obesity disorders.
Q4 2025 preliminary unaudited net revenues were approximately $57M, an 11% increase quarter-over-quarter, with FY 2025 revenues at ~$194M.
Cash, cash equivalents, and short-term investments totaled $416.1M as of September 30, 2025, sufficient to fund operations for at least 24 months.
Product pipeline and clinical development
Setmelanotide is advancing for acquired and congenital hypothalamic obesity, Prader-Willi syndrome, and additional rare MC4R pathway diseases.
Next-generation MC4R agonists, RM-718 (weekly injection) and oral bivamelagon, are in clinical development with patent protection into the 2040s.
Multiple clinical milestones are anticipated in 2026, including regulatory decisions, trial readouts, and pivotal trial initiations.
Market opportunity and patient impact
Significant market opportunities exist in acquired hypothalamic obesity (~10,000 US and EU prevalence each), Prader-Willi syndrome (~20,000 US, ~400,000 worldwide), and other rare genetic obesity disorders.
IMCIVREE is the first and only FDA- and EMA-approved therapy for early-onset, severe obesity and hyperphagia in Bardet-Biedl syndrome and certain genetic deficiencies.
Patient testimonials highlight transformative impacts on hunger and quality of life.
Initial acquired HO patient conversion expectations
Next-gen MC4R agonists' strategic importance
PWS trial data implications for broader use
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Next Rhythm Pharmaceuticals earnings date
Q4 202524 Feb, 2026
Rhythm Pharmaceuticals
Next Rhythm Pharmaceuticals earnings date
Q4 202524 Feb, 2026
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Frequently asked questions
Rhythm Pharmaceuticals Inc. is a biopharmaceutical company focused on developing treatments for rare genetic disorders related to obesity. The company’s primary area of focus is on conditions caused by impairments in the melanocortin-4 receptor (MC4R) pathway, which regulates hunger and body weight. Rhythm Pharmaceuticals aims to address unmet medical needs by developing targeted therapies that can help manage severe obesity and related symptoms in patients with specific genetic deficiencies. The company is headquartered in Boston, Massachusetts, and its shares are listed on the NASDAQ.
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