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GeneDx (WGS) investor relations material
GeneDx Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q3 2025 earnings summary28 Oct, 2025
Executive summary
Achieved Q3 2025 revenue of $116.7 million, up 52% year-over-year, with exome and genome test revenue rising 65–66% to $98.9 million.
Exome and genome test volume increased 33% year-over-year to 25,702, now representing 43% of all tests.
Adjusted gross margin expanded to 74% (from 64% in Q3 2024), and adjusted net income reached $14.7 million, marking the fifth consecutive profitable quarter.
Raised full-year 2025 revenue guidance to $425–$428 million, with exome and genome revenue growth guidance of 53–55%.
Granted FDA Breakthrough Device Designation for ExomeDx and GenomeDx tests; leadership in national genomic newborn screening initiatives.
Financial highlights
Diagnostic test revenue for Q3 2025: $113.5 million, up from $77.4 million in Q3 2024.
Adjusted gross margin: 74% in Q3 2025, up from 64% in Q3 2024; GAAP gross margin: 72%.
Adjusted net income: $14.7 million in Q3 2025; GAAP net loss: $7.6 million.
Cash, equivalents, and marketable securities totaled $156.1 million as of September 30, 2025.
Free cash flow generated: $8.8–9 million in Q3 2025.
Outlook and guidance
Full-year 2025 revenue guidance raised to $425–$428 million.
Exome and genome revenue expected to reach $358–$361 million, with 53–55% growth and at least 30% volume growth.
Adjusted gross margin guidance increased to 70–71% for 2025.
Positive adjusted net income expected each quarter and for the full year.
Management believes current liquidity is sufficient for at least twelve months from the filing date.
Projected revenue from gNBS initiatives?
Detail investments for sustainable growth.
FDA Breakthrough Device impact on market share?
Medi-Cal coverage impact on ASP and growth?
What steps are needed for pediatrician market ramp?
FDA breakthrough designation: what are next steps?
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Frequently asked questions
GeneDx Holdings Corp (formerly Sema4) is a patient-centered health intelligence company founded on the idea that more information, deeper analysis, and increased engagement will improve the diagnosis, treatment, and prevention of disease. This data-driven approach to making medicine more precise and personalized starts with patients, clinicians, and health system leaders working together with GeneDx.
Founded as Mount Sinai Health System’s predictive health initiative in 2013, GeneDx leverages Mount Sinai’s expertise in genomics, emerging technologies, and population health data to power its proprietary algorithms to drive insights and actions that empower individuals to live longer lives. GeneDx Holdings Corp is headquartered in Stamford, Connecticut.
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