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Edge20 Feb 2026
Dollar General: The Rural Retailer Playbook
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GeneDx
GeneDx (WGS) investor relations material
GeneDx Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 earnings summary23 Feb, 2026
Executive summary
Achieved Q4 2025 revenues of $121 million, up 27% year-over-year, with full-year revenues at $427.5 million, driven by 54% exome and genome revenue growth and strong test volumes.
Exome and genome revenues reached $104 million in Q4, up 32% year-over-year; organic growth rate was 42% excluding a one-time payor recovery.
Maintains leadership in rare disease diagnostics, supported by the largest and most diverse rare disease dataset (Infinity), broad adoption among geneticists and pediatric specialists, and recent FDA Breakthrough Device designation.
Expanded sales force from 60 to 160 reps and entered new markets including general pediatrics, NICU, prenatal, and adult neurology.
Reaffirmed 2026 guidance, projecting a breakout year with significant growth across multiple markets.
Financial highlights
Q4 2025 total revenues: $121 million (+27% YoY); exome/genome revenues: $104 million (+32% YoY); full year 2025 revenue: $427.5 million (+54% YoY).
Adjusted gross margin for Q4 and FY 2025: 71%, up from 65% in 2024 and 45% in 2023.
Adjusted net income: $4.4 million in Q4; $41.8 million for the full year.
Cash on hand at year-end 2025 was $172 million.
Exome/genome test volumes: 27,761 in Q4, with full year 2025 volume at 97,271, up 30.5% year-over-year.
Outlook and guidance
2026 revenue guidance: $540–$555 million; exome/genome volume growth of 33–35%.
Adjusted gross margin expected at ~70% for 2026; adjusted net income positive for the full year and each quarter.
Foundational markets expected to contribute 25–27% to growth; expansion markets 7–8%; future markets 1%.
Q1 2026 projected near breakeven due to front-loaded investments and seasonal factors.
Conservative assumptions for new market ramp, reimbursement, and Medicaid expansion; upside possible if adoption accelerates.
Cash flow from operations 2025 vs 2024
Impact of AAP guidance on pediatric market
How is GeneDx Infinity's data advantage leveraged?
Foundational market growth drivers for 2026
General pediatrics market entry strategy impact
Sustaining competitive moat with new technologies
Partial view of Summaries dataset, powered by Quartr API
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Next GeneDx earnings date
Barclays 28th Annual Global Healthcare Conference11 Mar, 2026
GeneDx
Next GeneDx earnings date
Barclays 28th Annual Global Healthcare Conference11 Mar, 2026
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Frequently asked questions
GeneDx Holdings Corp (formerly Sema4) is a patient-centered health intelligence company founded on the idea that more information, deeper analysis, and increased engagement will improve the diagnosis, treatment, and prevention of disease. This data-driven approach to making medicine more precise and personalized starts with patients, clinicians, and health system leaders working together with GeneDx.
Founded as Mount Sinai Health System’s predictive health initiative in 2013, GeneDx leverages Mount Sinai’s expertise in genomics, emerging technologies, and population health data to power its proprietary algorithms to drive insights and actions that empower individuals to live longer lives. GeneDx Holdings Corp is headquartered in Stamford, Connecticut.
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