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Summit Therapeutics (SMMT) investor relations material
Summit Therapeutics Jefferies London Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Jefferies London Healthcare Conference 2025 summary18 Nov, 2025
Company mission and strategic vision
Focused on making a significant difference for cancer patients through innovative therapies.
Ivonescimab, a PD-1 VEGF bispecific antibody, is the lead asset, aiming to improve efficacy and safety over existing standards.
Over 40,000 patients have received ivonescimab globally, with 14 phase III trials ongoing.
Four global studies are sponsored directly, with 10 additional trials in China.
Strategic collaborations and a robust pipeline extend beyond lung cancer.
Clinical data and safety profile
Ivonescimab has demonstrated strong tolerability, with recent HARMONi-6 data meeting its primary endpoint in progression-free survival.
Safety profile is consistent across regions and patient populations, including historically challenging squamous NSCLC.
Cooperative binding and shorter half-life contribute to reduced toxicity and improved efficacy.
Over 3,000 patients have been dosed in clinical settings, with a growing safety pool.
Efficacy and trial outcomes
HARMONi-6 showed a 0.60 hazard ratio, indicating a 40% improvement over standard of care in frontline NSCLC.
Median PFS difference of 11.1 vs. 6.8 months in Harmony 6, with positive physician feedback.
Four positive phase III trials have addressed key questions on efficacy and safety across diverse populations.
Consistent efficacy and safety results observed between Eastern and Western patient cohorts.
FDA's OS requirement for HARMONi BLA
HARMONi-3 split analysis impact on timelines
What is the strategy for novel combinations?
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Next Summit Therapeutics earnings date
Citi Annual Global Healthcare Conference 20252 Dec, 2025
Next Summit Therapeutics earnings date
Citi Annual Global Healthcare Conference 20252 Dec, 2025
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Leroy DaleyApp Store
One of the very few apps you could call perfect. If something was to add to it, maybe the share price of the company when you search for it, but it's already excellent.
Eferix Drawings Google Play
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Frequently asked questions
Summit Therapeutics Inc., headquartered in Menlo Park, California, is a biopharmaceutical company engaged in the research and development of oncology therapies in the United States and the United Kingdom. Its lead pipeline product, ivonescimab, is a novel, bispecific antibody targeting both PD-1 and VEGF. Summit Therapeutics has also initiated two clinical trials with ivonescimab. Additionally, the company's product pipeline includes SMT-738, a novel class of precision antibiotics aimed at treating multidrug-resistant infections, including carbapenem-resistant Enterobacteriaceae infections. The company is headquartered in Menlo Park, California, and its shares are listed on the Nasdaq.
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