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Syndax Pharmaceuticals (SNDX) investor relations material
Syndax Pharmaceuticals Guggenheim Securities Emerging Outlook: Biotech Summit 2026 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Financial performance and product growth
Achieved standout annual revenue with $125M in Revuforj sales and $152M in Niktimvo sales in the first 11 months on the market, both showing strong quarter-over-quarter growth.
Revuforj saw 38% growth in Q4, driven by expanded indications and increased patient penetration, especially in KMT2A and NPM1.
Maintenance therapy uptake in KMT2A patients post-transplant reached 35%-40%, with expectations to grow to 70%-80% over time.
Both products are expected to continue meaningful expansion, with significant milestones anticipated through 2026.
Operating expenses are being kept flat at $400M, supporting a clear path to profitability without additional funding needs.
Product development and clinical milestones
Revuforj is expanding into new indications, including NPM1, with strong physician awareness and anticipation for broader use.
Real-world and clinical data supporting maintenance therapy are being generated and will be presented at medical conferences in 2026.
Revuforj is being explored for myeloproliferative neoplasms (MPN), with preclinical data showing promise and clinical trials planned.
Niktimvo is approved for later-line chronic GVHD, with ongoing trials in earlier lines and combinations expected to read out in 2027 and 2028.
IPF phase II trial for axatilimab is fully enrolled, with data expected in the second half of 2026; positive results could lead to phase III development.
Market strategy and partnerships
Revuforj aims for dominant market share in both KMT2A and NPM1, leveraging best-in-class efficacy and physician education.
Niktimvo's U.S. commercialization is a 50/50 profit split with Incyte, with 25%-30% of net sales recognized as collaboration revenue.
Incyte is running key trials to expand Niktimvo's use in GVHD, including ex-U.S. markets.
Collaboration with Incyte for IPF and other indications involves shared costs (55% Incyte, 45% partner) for future trials.
Lifecycle management strategies are in place to maximize value from both franchises through new indications and global expansion.
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