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Trevi Therapeutics (TRVI) investor relations material
Trevi Therapeutics Morgan Stanley 23rd Annual Global Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Morgan Stanley 23rd Annual Global Healthcare Conference summary9 Sep, 2025
Company overview and drug mechanism
Focused on a single drug with a mixed agonist-antagonist opioid mechanism, offering efficacy and safety without addiction risk.
The drug targets chronic cough in three indications: IPF, non-IPF ILDs, and refractory chronic cough.
Mechanism acts both centrally and peripherally, differentiating it from competitors.
Clinical development and trial design
Strong phase 2b data in IPF; phase 3 program to start next year with similar endpoints but longer duration.
Planned parallel studies in IPF and non-IPF ILDs, leveraging overlapping patient populations and centers.
Placebo response in IPF trials is low and manageable; higher in RCC, requiring careful trial design.
Sample size for phase 3 IPF set at ~250 patients per arm to ensure safety and efficacy data.
Adaptive powering and sample size re-estimation planned for non-IPF ILD study.
Competitive landscape and differentiation
No approved therapies for cough in IPF/ILDs; current antifibrotics do not address cough.
Only one other asset in development for ILDs, with a peripheral-only mechanism and prior failures in RCC.
Ex-U.S. approved RCC drugs face U.S. commercialization challenges; current therapies have limited efficacy.
How does the ILD strategy impact market entry?
Impact of abuse potential on commercial strategy?
Mitigating placebo response in chronic cough trials?
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Next Trevi Therapeutics earnings date
Q3 20255 Nov, 2025
Next Trevi Therapeutics earnings date
Q3 20255 Nov, 2025
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Frequently asked questions
Trevi Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing treatments for serious neurological conditions. The company's lead therapeutic candidate targets chronic pruritus (itching) and other disorders related to the central and peripheral nervous systems. Trevi's drug development efforts aim to address unmet needs in conditions where current therapies are limited or ineffective. The company serves the healthcare sector, particularly in neurology and dermatology, with a focus on advancing innovative solutions for challenging medical conditions. The company is headquartered in New Haven, Connecticut, and its shares are listed on the NASDAQ.
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