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Vaxart (VXRT) investor relations material
Vaxart Global BioInnovation Forum 2026 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Innovation in vaccine delivery
Focus on oral recombinant pill vaccines to replace traditional injections, aiming for greater convenience and accessibility.
Technology leverages mucosal immunology to induce IgA antibodies at pathogen entry points, enhancing cross-protection.
Platform allows rapid adaptation to new pathogens by inserting genes of interest into a stable adenoviral vector.
Tablets are thermostable, easy to distribute, and eliminate the need for cold chain logistics and medical waste.
Oral vaccines can be self-administered, increasing global access and potentially improving vaccination rates.
Clinical and preclinical data highlights
Preclinical studies in animal models demonstrated reduced transmission and cross-protection against multiple strains.
Norovirus challenge studies showed prevention of infection and robust immune responses in diverse populations, including lactating mothers and the elderly.
COVID-19 oral vaccine produced strong mucosal and T-cell responses in phase 1 trials.
Influenza oral vaccine reduced symptomatic infection more than a leading injected vaccine in head-to-head studies.
Safety profile across nearly 1,200 subjects is comparable to placebo, with no injection site reactions.
Forward-looking statements and upcoming milestones
Top-line results from a 400-person COVID-19 trial comparing oral and mRNA vaccines expected in Q1 2026.
Larger 5,000-subject COVID-19 trial results anticipated in late 2026.
Phase 2b norovirus vaccine study could begin as early as 2026, following strong head-to-head data.
Ongoing development of seasonal and avian influenza programs, leveraging rapid platform adaptability.
Emphasis on the potential for the oral platform to revolutionize vaccine distribution and acceptance.
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