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Vaxart (VXRT) investor relations material
Vaxart H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Platform innovation and differentiation
Oral pill vaccine platform induces both systemic and mucosal immunity, is thermally stable for easy distribution and self-administration, and aims to address limitations of traditional injectable vaccines, including cold chain requirements and limited immune response.
Modular platform supports rapid adaptation for norovirus, COVID-19, flu, and potentially HPV, with favorable safety and tolerability in over 1,100 participants dosed to date.
Manufacturing and operations are U.S.-based, supporting domestic production, supply chain resilience, and rapid response.
Clinical pipeline and efficacy data
Broad pipeline includes clinical-stage programs for norovirus, COVID-19, influenza, and preclinical HPV vaccine.
Phase 2 norovirus challenge study showed 30% reduction in infection and 21% reduction in acute gastroenteritis symptoms, with next-generation candidate demonstrating significant increases in neutralizing antibodies (141% for Gl.1, 94% for GII.4).
BARDA-funded, head-to-head phase 2B trial of oral COVID-19 vaccine versus mRNA vaccine is ongoing with ~5,000 subjects enrolled; 12-month efficacy data expected in late 2026.
Influenza oral vaccine showed 49% reduction in infection versus placebo in phase 2 challenge, at least comparable to a leading injectable, and preclinical H5N1 study in ferrets showed 100% survival.
Strategic outlook and milestones
Cash runway extends into Q1 2026, supporting near-term milestones and ongoing development.
Norovirus phase 2B study targeted for late 2025, with phase 3 possible in 2026 and no current FDA-approved competitors.
COVID-19 trial data from sentinel cohort expected in Q1 2026; influenza program continues for both seasonal and avian strains, pending funding.
BARDA Project NextGen award of up to $460.7M funds pivotal COVID-19 trial.
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