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Vaxart (VXRT) investor relations material
Vaxart H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H.C. Wainwright 27th Annual Global Investment Conference summary8 Sep, 2025
Platform innovation and differentiation
Oral pill vaccine platform induces both systemic and mucosal immunity, is thermally stable for easy distribution and self-administration, and aims to address limitations of traditional injectable vaccines, including cold chain requirements and limited immune response.
Modular platform supports rapid adaptation for norovirus, COVID-19, flu, and potentially HPV, with favorable safety and tolerability in over 1,100 participants dosed to date.
Manufacturing and operations are U.S.-based, supporting domestic production, supply chain resilience, and rapid response.
Clinical pipeline and efficacy data
Broad pipeline includes clinical-stage programs for norovirus, COVID-19, influenza, and preclinical HPV vaccine.
Phase 2 norovirus challenge study showed 30% reduction in infection and 21% reduction in acute gastroenteritis symptoms, with next-generation candidate demonstrating significant increases in neutralizing antibodies (141% for Gl.1, 94% for GII.4).
BARDA-funded, head-to-head phase 2B trial of oral COVID-19 vaccine versus mRNA vaccine is ongoing with ~5,000 subjects enrolled; 12-month efficacy data expected in late 2026.
Influenza oral vaccine showed 49% reduction in infection versus placebo in phase 2 challenge, at least comparable to a leading injectable, and preclinical H5N1 study in ferrets showed 100% survival.
Strategic outlook and milestones
Cash runway extends into Q1 2026, supporting near-term milestones and ongoing development.
Norovirus phase 2B study targeted for late 2025, with phase 3 possible in 2026 and no current FDA-approved competitors.
COVID-19 trial data from sentinel cohort expected in Q1 2026; influenza program continues for both seasonal and avian strains, pending funding.
BARDA Project NextGen award of up to $460.7M funds pivotal COVID-19 trial.
COVID-19 stop order: How does it impact funding?
Norovirus funding: What's the partnership status?
Flu program: How to leverage superior efficacy?
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Next Vaxart earnings date
Q3 202512 Nov, 2025
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Frequently asked questions
Vaxart Inc. is a biotechnology company focused on developing oral vaccines that are administered using tablet formulations rather than injections. The company's proprietary oral vaccine platform is designed to stimulate immune responses in mucosal tissues, which are the first line of defense against many infections. Vaxart's vaccine candidates target a range of infectious diseases, including influenza, norovirus, and COVID-19. The company is headquartered in South San Francisco, California, and its shares are listed on the NASDAQ.
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