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Werewolf Therapeutics (HOWL) investor relations material
Werewolf Therapeutics H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H.C. Wainwright 27th Annual Global Investment Conference summary8 Sep, 2025
Platform innovation and differentiation
Utilizes native cytokines with advanced masking and protease-cleavable linker technology to minimize systemic toxicity and enable conditional activation in the tumor microenvironment.
Linker sequences are selected based on cleavage across diverse tumor types, confirmed in over 100 patient samples, ensuring broad applicability and minimal activation in healthy tissue.
Half-life extension allows for less frequent dosing and improved patient convenience.
Clinical assays confirm effective linker cleavage in the vast majority of patients, supporting the platform's reliability.
Clinical progress and data highlights
WTX-124 demonstrates a differentiated safety profile, avoiding vascular leak syndrome and showing a strong therapeutic index compared to high-dose IL-2.
Clinical data reveal anti-tumor and biomarker activity, with a recommended dose of 18 mg for both monotherapy and combination settings.
Expansion arms target renal cell carcinoma, melanoma, cutaneous squamous cell carcinoma, and non-small cell lung cancer.
Notable complete response in a cutaneous squamous cell carcinoma patient maintained for over a year off therapy.
Ongoing FDA discussions aim to define the registrational path, with a focus on advanced metastatic melanoma.
Pipeline and resource allocation
Majority of resources are allocated to advancing WTX-124, the lead clinical asset.
T-cell engager portfolio is progressing, with a second nomination expected by year-end and lessons from WTX-124 applied to improve therapeutic index.
Business development activities are active for both the T-cell engager program and lead assets.
A second INDUKINE development candidate, STEP1, is planned for announcement by year-end.
Rationale for single-arm melanoma registrational trial
WTX-330 strategy for non-inflamed tumors
T-cell engager BD strategy and next nomination
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Next Werewolf Therapeutics earnings date
Q3 20256 Nov, 2025
Next Werewolf Therapeutics earnings date
Q3 20256 Nov, 2025
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Frequently asked questions
Werewolf Therapeutics Inc. is a biopharmaceutical company focused on developing immunotherapies for cancer. The company specializes in engineered cytokine therapies designed to activate the immune system selectively within the tumor microenvironment. Its research and development efforts aim to enhance the efficacy and safety of immuno-oncology treatments through protein engineering and targeted delivery mechanisms. The company is headquartered in Watertown, Massachusetts, and its shares are listed on the NASDAQ.
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