Xenon Pharmaceuticals
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Xenon Pharmaceuticals (XENE) investor relations material

Xenon Pharmaceuticals 44th Annual J.P. Morgan Healthcare Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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44th Annual J.P. Morgan Healthcare Conference summary12 Jan, 2026

Strategic objectives and leadership

  • Aims to become a fully integrated biopharma company, focusing on discovering, developing, and commercializing CNS ion channel molecules.

  • Recent hires in commercial and financial leadership bring experience in transitioning to a commercial organization.

  • Early investment in building relationships within the epilepsy community and assembling a team with deep epilepsy expertise.

Corporate and financial overview

  • Neuroscience-focused biopharma with expertise in small molecule, ion channel drug discovery and development.

  • $555.3M in cash and equivalents as of September 30, 2025, with runway into 2027.

  • Pipeline includes sodium and potassium channel modulators for epilepsy, pain, and neuropsychiatry.

Lead asset: azetukalner clinical progress

  • Azetukalner is a potent Kv7 channel opener, the most advanced Kv7 modulator, in six ongoing phase III trials: three in epilepsy and three in neuropsychiatry.

  • Over 800 patient-years of efficacy and safety data for azetukalner.

  • X-TOLE2 phase III trial in focal onset seizures completed randomization; top-line data expected in March 2026.

  • X-TOLE3 includes Japanese subjects, enabling global regulatory alignment without separate Japanese trials.

  • Phase III trial in primary generalized tonic-clonic seizures is ongoing.

AZK's ease of use for general neurologists?
Rationale for HAM-D17 as MDD primary endpoint?
XEN1701's unique profile for NaV1.7 pain?
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Frequently asked questions

Xenon Pharmaceuticals Inc. is a clinical-stage biopharmaceutical company focused on developing innovative therapeutics for neurological disorders. The company leverages its expertise in ion channel biology to advance a pipeline of small-molecule therapies aimed at treating conditions such as epilepsy, rare neurological diseases, and other central nervous system disorders. The company is headquartered in Burnaby, Canada, and its shares are listed on the NASDAQ.

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