Kane Biotech (KNE) Investor presentation summary

The escalating burden of chronic wounds

• Over 130,000 amputations occur annually among diabetic patients in the US, with a similar crisis in Canada, where direct wound care costs exceed $12 billion CAD per year.

• Chronic wounds and burns represent a massive economic burden, with average treatment costs exceeding $100,000 USD per burn and $47,000 CAD per diabetic amputation.

• First Nations people in Canada face amputation rates up to 18 times higher than the general population in some regions.

Biofilms: The hidden barrier to healing

• Biofilms are present in 70% of burn wounds and 80% of chronic wounds, making bacteria up to 1,000 times more resistant to antibiotics.

• Standard treatments often fail because they do not disrupt biofilms, allowing infections to persist and wounds to remain non-healing.

Limitations of current wound care solutions

• Existing treatments like surgical debridement, antibiotics, and hydrogels have critical gaps: poor biofilm penetration, high costs, pain, and limited antimicrobial duration.

• No current solution combines biofilm disruption, sustained antimicrobial action, ease of use, and reimbursement.