Praxis Precision Medicines (PRAX) Proxy filing summary

Voting matters and shareholder proposals

• Election of three Class III Directors to serve until the 2029 Annual Meeting, with nominees Gregory Norden, Marcio Souza, and William Young recommended for election.

• Ratification of Ernst & Young LLP as the independent registered public accounting firm for the fiscal year ending December 31, 2026.

• Advisory (non-binding) vote to approve the compensation of named executive officers as disclosed in the proxy statement, including Compensation Discussion and Analysis and related tables.

• Authorization to transact any other business that may properly come before the meeting or any adjournment or postponement.

Board of directors and corporate governance

• Board recommends the election of all three Class III Director nominees for terms expiring at the 2029 Annual Meeting.

Executive compensation and say-on-pay

• Shareholders are asked to approve, on an advisory basis, the compensation of named executive officers as detailed in the proxy statement.