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Aardvark Therapeutics (AARD) investor relations material

Aardvark Therapeutics Evercore ISI 8th Annual HealthCONx Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Evercore ISI 8th Annual HealthCONx Conference summary4 Dec, 2025

Technology overview

  • Oral small molecule drug is gut-restricted, activating gut-brain signaling via the vagus nerve to regulate hunger by inducing gut peptide hormone release through GPCR engagement on enteroendocrine cells.

  • Single agent (ARD-101) targets rare disease; combination with Sitagliptin is for general obesity, leveraging mechanistic rationale for both.

  • ARD-101 engages bitter taste receptors in the gut, stimulating hormone release that signals satiety to the brain.

  • Combination with Sitagliptin prolongs the activity of gut hormones by inhibiting DPP-4, enhancing anti-appetite effects.

  • Drug formulation avoids taste issues by releasing contents only in the gut.

Clinical data and development status

  • Monotherapy showed 1.3 kg weight loss over 28 days in a phase 2 obesity study without diet or exercise; comparable to Semaglutide's 1.6 kg in similar timeframe.

  • Combination therapy demonstrated 19% body weight loss in high-fat-fed mouse model, nearly matching Tirzepatide's 20.5%.

  • No clinical data yet for the combination in humans; the POWER trial will address this.

  • Phase 3 HERO trial in Prader-Willi syndrome began dosing in Q2 2024, with top-line data expected Q3 2026.

Competitive landscape and differentiation

  • ViCat (diazoxide choline) is a recent competitor, approved for hyperphagia but has exclusions for renal insufficiency and risk of hyperglycemia.

  • ARD-101 does not have renal exclusions and may improve insulin sensitivity, based on clinical and preclinical data.

  • Both drugs use the same HQ-CT9 endpoint for hyperphagia; even a one-point reduction is considered clinically meaningful.

  • ARD-101 is not mutually exclusive with ViCat and may be suitable for patients unable to tolerate ViCat.

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Frequently asked questions

Aardvark Therapeutics Inc is a U.S.-based biotechnology company focused on the development of small molecule therapeutics for the treatment of metabolic and inflammatory diseases. The company engages in research and clinical development aimed at modulating specific biological pathways to address unmet medical needs. Aardvark Therapeutics operates through internal R&D efforts and collaborations with academic and industry partners. The company is headquartered in San Diego, California, and its shares are listed on the NASDAQ.

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