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Absci (ABSI) investor relations material
Absci Guggenheim Securities 2nd Annual Healthcare Innovation Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Company background and technology
Originated as a platform for scaling protein-protein interactions, later pivoted to generative AI for drug creation, focusing on engineering antibodies for specific properties.
Uses generative design to target hard-to-drug proteins like GPCRs and ion channels, aiming for first-in-class and best-in-class assets.
Pipeline includes a TL1A asset and ABS-201, targeting the prolactin receptor for androgenic alopecia and endometriosis.
Lead program (ABS-201) and clinical development
ABS-201 blocks the prolactin receptor, showing superior efficacy to minoxidil in preclinical studies and strong durability for hair regrowth.
First clinical dosing planned for December, with proof-of-concept readout expected in the second half of the following year.
The trial includes SAD and MAD portions, focusing on safety, tolerability, and efficacy using validated hair count measures.
Secondary endpoints include hair density, thickness, and pigmentation.
Market opportunity and commercialization strategy
Large market potential for androgenic alopecia, with high patient willingness to pay and significant unmet need, especially among women.
ABS-201 offers potential for long-lasting results with two to three injections, differentiating from daily treatments like minoxidil.
Initial commercialization will target physicians, with a long-term shift to direct-to-consumer, leveraging partnerships with telehealth platforms.
Go-to-market setup leverages dermatology, medispa, and plastic surgery channels, with a streamlined sales force compared to traditional pharma.
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