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Absci (ABSI) investor relations material

Absci H.C. Wainwright 27th Annual Global Investment Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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H.C. Wainwright 27th Annual Global Investment Conference summary9 Sep, 2025

Platform and business strategy

  • Focuses on AI-driven generative design for novel antibody therapeutics, targeting hard-to-drug biologics rather than small molecules.

  • Differentiates by integrating wet lab validation with rapid, scalable data generation and screening for protein-protein interactions.

  • Strategic shift from early-stage partnerships to advancing internal pipeline assets further before partnering, aiming for higher deal values.

  • Maintains a partnership model but now seeks to partner at later development stages or commercialize select assets independently.

  • Expects to announce a new large pharma partnership within the year, separate from internal program deals.

Pipeline highlights and clinical development

  • ABS201 targets the prolactin receptor for androgenetic alopecia, aiming for a convenient, durable injectable treatment with broad patient applicability.

  • Preclinical data in non-human primates show durable hair regrowth after limited dosing, supporting the product's design for infrequent administration.

  • Phase 1/2A trial for ABS201 expected to start in early 2026 or sooner, with interim proof-of-concept data anticipated in the second half of next year.

  • ABS101, targeting TL1A for IBD, is in phase 1 with interim data expected in the second half of this year; designed for higher affinity, potency, and convenient subcutaneous dosing.

  • Plans to partner ABS101 after phase 1 interim results, with ongoing discussions and sufficient capital to advance further if needed.

Competitive positioning and market opportunity

  • ABS201 offers potential advantages over competitors, including superior stability, solubility, extended half-life, and fewer required doses.

  • Market for androgenetic alopecia is large, with 80 million affected in the U.S.; product positioned for cash-pay model due to limited insurance coverage.

  • Existing treatments for hair loss have limited efficacy, poor adherence, or side effects, highlighting unmet need for a safe, convenient, and effective option.

  • ABS101 aims to differentiate from first-generation anti-TL1A antibodies with improved pharmacokinetics and dosing convenience.

  • Both internal and partnered programs are expected to drive near-term value inflection points.

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Frequently asked questions

Absci Corporation operates as a generative AI drug creation company, focusing on revolutionizing the process of biologics drug discovery. Leveraging an integrated drug creation platform, Absci identifies novel drug targets and creates biotherapeutic candidates, shifting from traditional drug discovery to drug creation. This approach enables the design of de novo antibodies directly on computers, potentially reducing the development time for new drug leads and increasing their probability of success. The company's platform combines artificial intelligence with synthetic biology, allowing the construction and testing of millions of AI designs weekly. This innovative process results in wet lab-validated biologic-based therapeutics in a significantly shortened timeframe, aiming to address the challenges of traditionally high failure rates and lengthy development times in biologics drug discovery. The company is headquartered in Vancouver, Washington, and its shares are listed on the Nasdaq.

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